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A toolkit developed to predict and analyze PROTAC-mediated ternary complexes using AlphaFold3 and Boltz-1.

Python 40 5 Updated Jul 17, 2025
Python 4 2 Updated Oct 28, 2025
Python 3 Updated Jan 12, 2026

Training and inference code for ShEPhERD: Diffusing shape, electrostatics, and pharmacophores for bioisosteric drug design [ICLR 2025 oral]

Python 88 10 Updated Jan 29, 2026

Interaction profile extraction, scoring, alignment and evaluation of ShEPhERD. [ICLR 2025]

Python 33 9 Updated Jan 29, 2026

Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models

Python 950 269 Updated Jul 8, 2024
Python 73 11 Updated Jan 11, 2025

An automated scoring function to facilitate and standardize the evaluation of goal-directed generative models for de novo molecular design

Python 222 34 Updated Jan 20, 2026

Flexible and powerful tensor operations for readable and reliable code (for pytorch, jax, TF and others)

Python 9,391 390 Updated Jan 26, 2026

[ICML 25'] Compositional Flows for 3D Molecule and Synthesis Pathway Co-design

Jupyter Notebook 12 1 Updated Dec 1, 2025

A neurosymbolic perspective on LLMs

Python 1,666 84 Updated Feb 6, 2026

Official repository for the Boltz biomolecular interaction models

Python 3,733 747 Updated Oct 3, 2025
Python 56 9 Updated Dec 5, 2025

Synthesis-oriented GFlowNets on a large action space: "Generative Flows on Synthetic Pathway for Drug Design" (ICLR 2025)

Python 31 5 Updated Oct 23, 2025

AI molecular design tool for de novo design, scaffold hopping, R-group replacement, linker design and molecule optimization.

Python 681 196 Updated Jan 21, 2026
Jupyter Notebook 3 Updated Mar 6, 2025
Python 5 1 Updated Mar 10, 2025

Interaction Fingerprints for protein-ligand complexes and more

Python 474 94 Updated Feb 11, 2026

Inference code for scalable emulation of protein equilibrium ensembles with generative deep learning

Python 747 123 Updated Feb 5, 2026

Fast AlphaFold-Multimer based pipeline for Protein-Protein Interaction (PPI) screening

Python 39 3 Updated Sep 27, 2024

Efficient 3D molecular generation with flow-matching and Semla

Python 54 10 Updated Jul 22, 2025
Python 15 2 Updated Apr 9, 2024

Python module which allows you to specify timeouts when calling any existing function, and support for stoppable threads

Python 331 37 Updated Mar 1, 2024

🦉 A grounder and solver for logic programs.

C++ 748 92 Updated Feb 9, 2026
Python 283 52 Updated Feb 11, 2026

Graph neural networks for molecular design.

Python 379 74 Updated Mar 11, 2023