Presto performs a fast Wilcoxon rank sum test and auROC analysis. Latest benchmark ran 1 million observations, 1K features, and 10 groups in 16 seconds (sparse input) and 85 seconds (dense input).

Install presto:

# install.packages("devtools")
devtools::install_github("immunogenomics/presto")

Run presto on a matrix, Seurat, or SingleCellExperiment input object.

wilcoxauc(X, y)
wilcoxauc(seurat_object, 'group_name')
wilcoxauc(sce_object, 'group_name')

For examples, see ?wilcoxauc and the vignette