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  2. Programmed death-ligand 1 (PD-L1) is a well-recognized predictive biomarker for immunotherapy in non-oncogene-addicted non-small cell lung cancer (NSCLC). However, its role in epidermal growth factor receptor (EG...

    Authors: Chia-Chi Hsu, Derek De-Rui Huang, Wei-Hsun Hsu, Min-Shu Hsieh, Fang-Yu Lin, Pei-Chen Tai, Shih-Yun Chou, Hsin-Hui Tsai, Chen-Yuan Tseng, Bin-Chi Liao, Jin-Yuan Shih and James Chih-Hsin Yang
    Citation: Journal of Biomedical Science 2025 32:94
    Content type: Research Published on:

  5. While the Warburg effect links glycolysis to de novo lipid synthesis in carcinogenesis, the roles of lipids in cancer prognosis remain elusive. Here, a multi-omics approach was conducted in a cohort of hepatoc...

    Authors: Pei-Yin Liao, Wen-Jen Lin, Pei-Chun Shen, Cian-Ru Yang, Ying-Chun Yu, Chun-Chieh Yeh, Long-Bin Jeng, Hsieh-Chou Lai, Wei-Chung Cheng and Wen-Lung Ma
    Citation: Journal of Biomedical Science 2025 32:89
    Content type: Research Published on:

  6. PPM1D (protein phosphatase Mg2⁺/Mn2⁺ dependent 1D) is a Ser/Thr phosphatase that negatively regulates p53 and functions as an oncogenic driver. Its gene amplification and overexpression are frequently observed in...

    Authors: Masaki Takahashi, Takeshi Kondo, Shogo Kimura, Akira Nakazono, Shusei Yoshida, Takeshi Wada, Masashi Watanabe and Shigetsugu Hatakeyama
    Citation: Journal of Biomedical Science 2025 32:88
    Content type: Research Published on:

  8. Enteroviruses, including Coxsackie B (CVB) viruses, can cause severe diseases such as myocarditis, pancreatitis, and meningitis. Vaccines can prevent these complications, but conserved non-neutralizing epitope...

    Authors: Saana Soppela, Martín González-Rodríguez, Virginia M. Stone, Iiris Mustonen, Niila V. V. Jouppila, Vili Lampinen, Teemu Haikarainen, Malin Flodström-Tullberg, Ilkka S. Junttila and Minna M. Hankaniemi
    Citation: Journal of Biomedical Science 2025 32:86
    Content type: Research Published on:

  10. Exposure of mammals to ototoxic compounds causes hair cell (HC) loss in the vestibular sensory epithelia of the inner ear. In chronic exposure models, this loss often occurs by extrusion of the HC from the sen...

    Authors: Mireia Borrajo, Erin A. Greguske, Alberto F. Maroto, Aïda Palou, Ana Renner, Víctor Giménez-Esbrí, David Sedano, Marta Gut, Anna Esteve-Codina, Beatriz Martín-Mur, Alejandro Barrallo-Gimeno and Jordi Llorens
    Citation: Journal of Biomedical Science 2025 32:84
    Content type: Research Published on:

  11. Aging is the foremost risk factor for metabolic syndrome and atherosclerosis, which is a principal cause of cardiovascular diseases (CVDs). Vascular endothelial cells (ECs), which line the vascular intima, pla...

    Authors: Wei-Li Wang, Yu-Tsung Shih, Shu-Yi Wei and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2025 32:83
    Content type: Review Published on:

  12. Brain-derived neurotrophic factor (BDNF) is a key mediator of synaptic plasticity and memory formation in the hippocampus. However, the BDNF-induced alterations in the glutamate receptors coupled to the plasti...

    Authors: Pasqualino De Luca, Miranda Mele, Sara Tanqueiro, Francesca Napoli, Ugné Butkevičiūtė, Arthur C. Souto, Rui O. Costa, Alexander Schwarz, Meinrad Drexel, Ana M. Sebastião, Maria J. Diógenes and Carlos B. Duarte
    Citation: Journal of Biomedical Science 2025 32:82
    Content type: Research Published on:

  13. Growing evidence highlights the importance of epitranscriptomic regulation in cerebellar development and function, especially through m6A methylation. Nevertheless, the precise function of the RNA demethylase Fto...

    Authors: Jing Jiang, Ming Zhang, Wenjuan Xia, Chenyue Ding, Jincheng Li, Xiujuan Hu, Jiafeng Lu, Hong Li, Qingxia Meng, Hoi-Hung Cheung and Boxian Huang
    Citation: Journal of Biomedical Science 2025 32:81
    Content type: Research Published on:

  14. Authors: Yasufumi Katanasaka, Yoichi Sunagawa, Ryoga Sakurai, Mikuto Tojima, Ryuya Naruta, Yuya Hojo, Yuto Kawase, Toshihide Hamabe‑Horiike, Kiyoshi Mori, Koji Hasegawa and Tatsuya Morimoto
    Citation: Journal of Biomedical Science 2025 32:80
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2025 32:61

  15. Triple-negative breast cancer (TNBC) has the highest mortality rate among all breast cancer subtypes. Although immunotherapy shows promise, its efficacy varies. CDK4/6 inhibitors can radiosensitize and modulat...

    Authors: Wen-Chi Yang, Ming-Feng Wei, Ying-Chun Shen, Chiun-Sheng Huang and Sung-Hsin Kuo
    Citation: Journal of Biomedical Science 2025 32:79
    Content type: Research Published on:

  16. The pineal gland produces melatonin to control circadian rhythm via the final enzyme in the serotonin pathway, hydroxyindole O-methyltransferase (HIOMT). Interestingly, HIOMT is expressed by certain non-pineal...

    Authors: Wei-Cheng Jiang, Chung-Huang Chen, Hua-Hui Ho, Pei-Yu Gung, Jing-Yiing Wu, Cheng-Chin Kuo, Kenneth K. Wu and Shaw-Fang Yet
    Citation: Journal of Biomedical Science 2025 32:78
    Content type: Research Published on:

  17. Postnatal skeletal muscle development leads to increased muscle mass, strength, and mitochondrial function, but the role of mitochondrial remodeling during this period is unclear. This study investigates mitoc...

    Authors: Fasih A. Rahman, Mackenzie Q. Graham, Alex Truong and Joe Quadrilatero
    Citation: Journal of Biomedical Science 2025 32:77
    Content type: Research Published on:

  18. Rickettsiosis is among the deadliest vector-borne infectious diseases worldwide, in part because rickettsiae replicate within human cells, where antibodies and most drugs cannot effectively reach this obligato...

    Authors: Qi Yan, Nan Duan, Mingqun Lin, Wenqing Zhang, Stephen Denton, Yichen Zhong, Yizhou Dong and Yasuko Rikihisa
    Citation: Journal of Biomedical Science 2025 32:76
    Content type: Research Published on:

  19. Pyruvate kinase M2 (PKM2) is a key enzyme involved in glycolysis, yet its role in cancer extends far beyond metabolic flux. Unlike its isoform PKM1, PKM2 exhibits unique regulatory properties due to alternativ...

    Authors: Tsan-Jan Chen, Chun-Hsien Wu, Mien-Chie Hung, Wen-Ching Wang and Hsing-Jien Kung
    Citation: Journal of Biomedical Science 2025 32:75
    Content type: Review Published on:

  20. Therapeutic options against metallo-β-lactamase producing P. aeruginosa (MBL-PA) are limited due to multi-drug resistance. A jumbo phage isolated from wastewater in Greece was characterized microbiologically and ...

    Authors: Paschalis Paranos, Dimitrios Skliros, Nikita Zrelovs, Panagiota-Christina Georgiou, Karina Svanberga, Andris Kazaks, Marios Kostakis, Nikolaos Thomaidis, Emmanouil Flemetakis and Joseph Meletiadis
    Citation: Journal of Biomedical Science 2025 32:74
    Content type: Research Published on:

  21. CD24 plays a crucial role not only in promoting tumor progression and metastasis but also in modulating macrophage-mediated anti-tumor immunity. However, its impact on the immune landscape of the tumor microen...

    Authors: Shih-Hsuan Chan, Chin-Yu Lin, Hsuan-Jung Tseng and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2025 32:73
    Content type: Research Published on:

  22. Taiwan has the highest prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) globally, making them major public health concerns with significant morbidity, mortality, and healthcare bu...

    Authors: Min-Rou Lin, I-Wen Wu, Wan-Hsuan Chou, Yung-Feng Lin, Kuan-Yu Hung, Kaname Kojima, Kosuke Shido, Kengo Kinoshita, Wei-Chiao Chang and Mai-Szu Wu
    Citation: Journal of Biomedical Science 2025 32:72
    Content type: Research Published on:

  23. Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to...

    Authors: Bo-Syong Pan, Che-Chia Hsu, Hsin-En Wu, Yuan-Ru Chen, Xiaobo Zhou, Shu-Chi Wang, Chia-Yang Li and Hui-Kuan Lin
    Citation: Journal of Biomedical Science 2025 32:71
    Content type: Review Published on:

  24. The application of smart hydrogels has become a booming research frontier in biomedical engineering. With the development of intelligent drug delivery systems, various biomimetic and biodegradable hydrogels ar...

    Authors: Shih-Ho Lin and Shan-hui Hsu
    Citation: Journal of Biomedical Science 2025 32:70
    Content type: Review Published on:

  25. Immunomodulatory agents benefit a small percentage of patients with oral cancer (OC), a subset of head and neck cancer. Cathepsin S (CTSS), a lysosomal protease, has been frequently associated with tumor immun...

    Authors: Yung-Chieh Chang, Szu-Jung Chen, Shang-Hung Chen, Sheng-Yen Hsiao, Li-Hsien Chen, Chung-Hsing Chen, Chan-Chuan Liu, Ya-Wen Chen, Ko-Jiunn Liu, Shang-Yin Wu, Jui-Mei Chu, Li-Ying Qiu, Wei-Fan Chiang, Hsing-Pang Hsieh, Wen-Yun Hsueh, Jenn-Ren Hsiao…
    Citation: Journal of Biomedical Science 2025 32:69
    Content type: Research Published on:

  26. The organic cation transporter 3 (OCT3) is a ubiquitous transporter that carries both endogenous and exogenous substrates, such as histamine and cisplatin. Our investigations have shown that OCT3 directly inte...

    Authors: Moritz Pernecker, Miriam Dibos, Sophie Götz, Rouvier Al-Monajjed, Vivien Barz, Christian Albiker, Rita Schröter, Ute Neugebauer, Lena Ludwig-Radtke, R. Verena Taudte, Thomas Vogl and Giuliano Ciarimboli
    Citation: Journal of Biomedical Science 2025 32:68
    Content type: Research Published on:

  27. Clinical research has identified stomach dysmotility as a common feature of obesity. However, the specific mechanisms driving gastric emptying dysfunction in patients with obesity remain largely unknown. In th...

    Authors: Sanaa Dekkar, Kamilia Mahloul, Amandine Falco, Karidia Konate, Romane Pisteur, Sarah Maurel, Laurent Maïmoun, Norbert Chauvet, Prisca Boisguérin, David Nocca, Ariane Sultan, Florian Pallot, Guillaume Walther, Nicolas Cenac, Cyril Breuker, Sandrine Faure…
    Citation: Journal of Biomedical Science 2025 32:67
    Content type: Research Published on:

  28. Adenosine is a ubiquitous endogenous molecule capable of influencing several pathophysiological aspects. The adenosine system is extremely complex, starting from the generation of intracellular and extracellul...

    Authors: Katia Fettucciari, Luigi Cari, Andrea Spaterna, Rachele Del Sordo, Filippo Tavanti, Pierfrancesco Marconi and Gabrio Bassotti
    Citation: Journal of Biomedical Science 2025 32:66
    Content type: Review Published on:

  29. Non-communicable chronic diseases are characterized by low-grade inflammation and oxidative stress. Extensive research has identified the transcription factor NRF2 as a potential therapeutic target. Current NR...

    Authors: Ángel J. García-Yagüe, Lucía Cañizares-Moscato, José Antonio Encinar, Eduardo Cazalla, Raquel Fernández-Ginés, Maribel Escoll, Ana I. Rojo and Antonio Cuadrado
    Citation: Journal of Biomedical Science 2025 32:65
    Content type: Research Published on:

  31. The airway epithelium represents the first line of defense of the lungs, functioning both as a physical barrier as well as an active immune modulator. However, in the last years, pneumonia caused by the opport...

    Authors: Daniela Scribano, Claudia Tito, Astri D. Tagueha, Martina Pasqua, Luciana De Angelis, Francesco Fazi, Dolores Limongi, Marta De Angelis, Lucia Nencioni, Anna Teresa Palamara and Cecilia Ambrosi
    Citation: Journal of Biomedical Science 2025 32:63
    Content type: Research Published on:

  32. Chitosan is a cationic natural polymer composed of glucosamine and N-acetylglucosamine residues that are held together by a glycosidic bond. Chitosan has many excellent properties, including physicochemical pr...

    Authors: Weronika Gonciarz, Ewa Balcerczak, Marek Brzeziński, Agnieszka Jeleń, Agnieszka J. Pietrzyk-Brzezińska, Vedha Hari B. Narayanan and Magdalena Chmiela
    Citation: Journal of Biomedical Science 2025 32:62
    Content type: Review Published on:

  33. Various epigenetic modifiers are involved in the regulation of gene expression during pathological cardiac hypertrophy—a critical event in the development of heart failure. Our previous research has demonstrat...

    Authors: Yasufumi Katanasaka, Yoichi Sunagawa, Ryoga Sakurai, Mikuto Tojima, Ryuya Naruta, Yuya Hojo, Yuto Kawase, Toshihide Hamabe-Horiike, Kiyoshi Mori, Koji Hasegawa and Tatsuya Morimoto
    Citation: Journal of Biomedical Science 2025 32:61
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2025 32:80

  34. Autism spectrum disorder (ASD) is characterized by disruption of the gut–brain axis, which leads to behavioral, psychiatric, metabolic and gastrointestinal symptoms. Effective ASD treatments are limited. Resea...

    Authors: Antonella Campanale, Dario Siniscalco and Vincenzo Di Marzo
    Citation: Journal of Biomedical Science 2025 32:60
    Content type: Review Published on:

  35. The COVID-19 pandemic continues to affect the world in 2025. The rapid mutation of SARS-CoV-2 results in breakthrough infections and diminishes the efficacy of vaccines and anti-viral drugs. The severity of th...

    Authors: Ming-Shiu Lin, Tai-Ling Chao, Yu-Chi Chou, Yao Yi, Ci-ling Chen, Kuo-Yen Huang, Sui-Yuan Chang and Pan-Chyr Yang
    Citation: Journal of Biomedical Science 2025 32:59
    Content type: Research Published on:

  36. Chagas disease, caused by Trypanosoma cruzi parasites, leads to chronic cardiac disease in 20–40% of infected patients, while the majority remain asymptomatic. The mechanisms and drivers of pathogenesis are still...

    Authors: Rachel M. Clear, Weihong Tu, Kelly Goff, Preston A. Marx, Claudia Herrera and Eric Dumonteil
    Citation: Journal of Biomedical Science 2025 32:58
    Content type: Research Published on:

  37. Traumatic Brain Injury (TBI) is a major risk factor for neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), with neuroinflammation playing a critical role in the secondar...

    Authors: Shih Chang Hsueh, Pathik Parekh, Buyandelger Batsaikhan, Neil Vargesson, David Tweedie, Weiming Luo, Chirag N. Patel, Dong Liu, Ross A. McDevitt, Abdul Mannan Baig, Yu Kyung Kim, Sun Kim, Inho Hwang, Juwan Kim, Mee Youn Lee, Anna R. Carta…
    Citation: Journal of Biomedical Science 2025 32:57
    Content type: Research Published on:

  38. The innate immune system is the host’s initial response to eliminate pathogens and repair tissue damage. Innate immune cells, such as macrophages and dendritic cells, use pattern recognition receptors (PRRs) t...

    Authors: You-Sheng Lin, Yung-Chi Chang, Tzu-Yu Pu, Tsung-Hsien Chuang and Li-Chung Hsu
    Citation: Journal of Biomedical Science 2025 32:56
    Content type: Review Published on:

  39. This study aimed to investigate whether probiotics can ameliorate the H. pylori-induced Wnt/β-catenin-related COX-2 carcinogenesis signaling pathway by regulating the expression of microRNAs (miRNAs).

    Authors: Yao-Jong Yang, Chung-Tai Wu, Hsiu-Chi Cheng, Wei-Ying Chen, Joseph T. Tseng, Wei-Lun Chang and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2025 32:55
    Content type: Research Published on:

  40. Ubiquitin-specific peptidase 24 (USP24), a deubiquitinating enzyme, regulates protein stability by removing ubiquitin. This study investigates the role of UPS24 in lipid metabolism, inflammation, and fibrosis....

    Authors: Beh Ning, Shao-An Wang, Ming-Jer Young, Yung-Ching Chen, Yun Hung, Tran Thu Huong, Wen-Chang Chang, Yi-Ching Wang, Ming-Lung Yu, Kai-Cheng Hsu and Jan-Jong Hung
    Citation: Journal of Biomedical Science 2025 32:54
    Content type: Research Published on:

  41. Acinetobacter baumannii is notorious for its antimicrobial resistance and its potential to cause epidemics in hospital settings, which pose a global health threat. Although this microorganism is traditionally con...

    Authors: Man Hwan Oh, Md Minarul Islam, Nayeong Kim, Chul Hee Choi, Minsang Shin, Woo Shik Shin and Je Chul Lee
    Citation: Journal of Biomedical Science 2025 32:53
    Content type: Review Published on:

  42. Effective subunit vaccine development requires selecting appropriate adjuvant formulations to trigger desired adaptive immune responses. This study explores the immunogenicity and tuberculosis (TB) vaccine pot...

    Authors: Kee Woong Kwon, Eunsol Choi, Hagyu Kim, Hyeong Woo Kim, Sangwon Choi, Seunghyun Lee, Sang-Jun Ha and Sung Jae Shin
    Citation: Journal of Biomedical Science 2025 32:52
    Content type: Research Published on:

  44. Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association stud...

    Authors: Min-Rou Lin, Cheng-Lin Tsai, Cai-Sian Liao, Chun-Yu Wei, Wan-Hsuan Chou, Tzu-Hung Hsiao and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2025 32:50
    Content type: Research Published on:

  45. Gemcitabine (GEM) is used as a first-line therapy for patients diagnosed with any stage of pancreatic cancer (PC); however, patient survival is poor because of GEM resistance. Thus, new approaches to overcome ...

    Authors: Eun-Jeong Jeong, Yuna Roh, Eunsun Jung, Jin-Seong Hwang, Taesang Son, Hyun Seung Ban, Tae-Su Han, Young-Kug Choo and Jang-Seong Kim
    Citation: Journal of Biomedical Science 2025 32:49
    Content type: Research Published on:

  46. Asthma is a chronic inflammatory lung disease driven by a complex interplay between innate and adaptive immune components. Among these, innate lymphoid cells (ILCs) and innate-like lymphocytes have emerged as ...

    Authors: Christina Li-Ping Thio, Jheng-Syuan Shao, Chia-Hui Luo and Ya-Jen Chang
    Citation: Journal of Biomedical Science 2025 32:48
    Content type: Review Published on:

  47. Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacer...

    Authors: Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai, Xin Xiao, Ben Wang, Zhili Deng and Ji Li
    Citation: Journal of Biomedical Science 2025 32:47
    Content type: Research Published on:

  49. The emergence of Artificial Intelligence (AI), particularly Chat Generative Pre-Trained Transformer (ChatGPT), a Large Language Model (LLM), in healthcare promises to reshape patient care, clinical decision-ma...

    Authors: Usman Iqbal, Afifa Tanweer, Annisa Ristya Rahmanti, David Greenfield, Leon Tsung-Ju Lee and Yu-Chuan Jack Li
    Citation: Journal of Biomedical Science 2025 32:45
    Content type: Research Published on:

  50. The evolution of SARS-CoV-2, particularly through new variants, presents significant global health challenges due to their potential for immune evasion and reduced vaccine effectiveness. This study aims to inv...

    Authors: Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2025 32:44
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127