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Personalized Immunotherapy Research Lab

Personalized Immunotherapy Research Lab

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Expanding the Unified Grammar for RNA Variants
A unified toolkit for identifying and integrating DNA and RNA variants. Part 2 of the Neoantigen Discovery with Long-read Sequencing series.
 • Jin Seok (Andy) Lee
Inversion: Temporal Pincer in Cancer Genome
Head-to-head (5' to 5') and tail-to-tail (3' to 3') inversion breakpoints explained.
 • Jin Seok (Andy) Lee
Announcing LENS v1.7
PIRL has been working hard to continuously improve our publicly available tumor antigen prediction workflow, Landscape of Effective Neoantigen Software…
 • Steven P. Vensko II
A Unifying Grammar for DNA Variants
A unified framework and toolkit for standardizing DNA variants at scale. Part 1 of the neoantigen discovery with long-read sequencing series.
 • Jin Seok (Andy) Lee
Potency of peptide + polyIC-LC +/- montanide vs CpG and mRNA/LNP for vaccination in C57Bl/6 mice.
Experiments here were planned, done, and reported by Jess Alley and Maria Sambade, with assistance from Blake Inabinett
 • Benjamin Vincent
Adding to our mRNA lipid nanoparticle characterization techniques
I recently ran a gel retardation assay using the mRNA lipid nanoparticles formulated in our lab, and I share the results below.
 • Jessica Alley
An experiment comparing the potency of vaccine formulations in C57BL/6 mice
Introducing the Optimizing Immunization Strategies for Therapeutic Efficacy and Response (OISTER) project
 • Benjamin Vincent
Personalized Immunotherapy Research Lab
Personalized Immunotherapy Research Lab
The Personalized Immunotherapy Research Lab (PIRL) at UNC
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