Hello there,

I have a problem about MethReg package recently.

For the first time, I used below version.

## MethReg_1.8.0 with JASPAR2022
region.tf <- get_tf_in_region(
      region = regions.names,
      genome = "hg38"
    )

And now, because of packages update, the package is changed.

## MethReg_1.13.5    with JASPAR2024
region.tf <- get_tf_in_region(
      region = regions.names,
      genome = "hg38"
    )

So the problem appeared. I got two quite different results for TFBs annotation.

the human motifs from JASPAR2022 and JASPAR2024 are not the same but also not so different.

For jaspar2022, the number of core human motifs of latest version: 727 from JASAPR2022 website and 692 from your pacakge.
For jaspar2024, the number of core human motifs of latest version: 755 from JASAPR2024 website and 720 from your pacakge.

For the second version, almost each region from my data can be annotated with many TFBs.

But in the first version, about 30% regions of my the same data annotated with zero TFBs.

I was really confused and don't know where the wrong is and how to process it .

I really hope that you can give me some advice.
Thank in advance.

Best,
Xiangyi