fig = plt.figure(constrained_layout=True, figsize=(10, 8))

# create top/bottom subfigs
# see https://stackoverflow.com/a/68553015/9249533
(subfig_t, subfig_b) = fig.subfigures(2, 1, hspace=0.05, height_ratios=[1, 3])

# put ax0 in top subfig
ax0 = subfig_t.subplots()

# create left/right subfigs nested in bottom subfig
(subfig_bl, subfig_br) = subfig_b.subfigures(1, 2, wspace=0.1, width_ratios=[3, 1])

# put ax1-ax3 in gridspec of bottom-left subfig
gs = subfig_bl.add_gridspec(nrows=1, ncols=9)

ax1 = subfig_bl.add_subplot(gs[0, :3])
ax2 = subfig_bl.add_subplot(gs[0, 3:6], sharey=ax1)
ax3 = subfig_bl.add_subplot(gs[0, 6:9], sharey=ax1)


ax1.set_title('Nov. 7 to Nov. 13')
ax2.set_title('Nov. 13 to Nov. 27')
ax3.set_title('Nov. 27 to Dec. 31')
ax2.get_yaxis().set_visible(False)
ax3.get_yaxis().set_visible(False)

subfig_bl.supxlabel("My Subfigure Label", x=0.54, size=12, fontweight='bold')

# put ax4 in bottom-right subfig
ax4 = subfig_br.subplots()
ax4.set_title('Some Other Title')
subfig_br.supxlabel('Other Subfigure SubLabel', size=12, fontweight='bold')