Human Anatomy & Physiology, 8e (Marieb/Hoehn)

Chapter 2 Chemistry Comes Alive

Matching Questions

Figure 2.1

Using Figure 2.1, match the following:

1) Lipid.
2) Functional protein.
3) Nucleotide.
4) Polysaccharide.
5) Monosaccharide.
6) Polymer.
7) Tertiary (protein) structure.

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Figure 2.2

Using Figure 2.2, match the following:

8) Deoxyribose sugar.
9) Thymine.
10) Guanine.
11) Phosphate.
12) Hydrogen bonds.

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Match the following chemical bonds to the correct description:

A) Ionic bond
B) Polar covalent bond
C) Hydrogen bond
D) Nonpolar covalent bond
13) A bond in which electrons are shared unequally.
14) A bond in which electrons are completely lost or gained by the atoms involved.
15) A bond in which electrons are shared equally.
16) A type of bond important in tying different parts of the same molecule together into a threedimensional structure.

Match the following particles to the correct description:

A) Neutron
B) Cation
C) Molecule
D) Atom
17) Electrically charged particle due to loss of an electron.
18) Neutral subatomic particle.
19) Smallest particle of an element that retains its properties.
20) Smallest particle of a compound that still retains its properties.

Match the following:

A) Mixture
B) Compound
C) Element
21) Water.
22) Carbon.
23) Dry ice (frozen carbon dioxide).
24) Blood.

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Match the following:

A) Weight
B) Matter
C) Energy
D) Mass
25) Can be measured only by its effects on matter.
26) Anything that occupies space and has mass.
27) Although a man who weighs 175 pounds on Earth would be lighter on the moon and heavier
on Jupiter, his ________ would not be different.
28) Is a function of, and varies with, gravity.

Match the following:

A) Electrical energy
B) Radiant energy
C) Mechanical energy
D) Chemical energy
29) Legs moving the pedals of a bicycle.
30) When the bonds of ATP are broken, energy is released to do cellular work.
31) Energy that travels in waves. Part of the electromagnetic spectrum.
32) Represented by the flow of charged particles along a conductor, or the flow of ions across a
membrane.

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Match the following:

A) Colloids
B) Suspensions
C) Solutions
33) Heterogeneous, will not settle.
34) Heterogeneous, will settle.
35) Homogeneous, will not settle.
36) Will not scatter light.

True/False Questions
1) The atomic weight is only an average of relative weights of an atom and its isotopes, and it
may vary from the weight of a specific isotope.
2) Emulsions and colloids are the same thing.
3) Chemical properties are determined primarily by neutrons.
4) A charged particle is generally called an ion.
5) Isotopes differ from each other only in the number of electrons contained.
6) About 60% to 80% of the volume of most living cells consists of organic compounds.
7) Lipids are a poor source of stored energy.
8) Current information theorizes that omega-3 fatty acids decrease the risk of heart disease.
9) Glucose is an example of a monosaccharide.
10) A molecule consisting of one carbon atom and two oxygen atoms is correctly written as CO2.
11) The lower the pH, the higher the hydrogen ion concentration.
12) Covalent bonds are generally less stable than ionic bonds.
13) Hydrogen bonds are comparatively strong bonds.
14) The fact that no chemical bonding occurs between the components of a mixture is the chief
difference between mixtures and compounds.
15) Alpha particles, although relatively weak energy particles, are second only to smoking as a
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cause of lung cancer.

16) No chemical bonding occurs between the components of a mixture.
17) All organic compounds contain carbon.
18) A dipeptide can be broken into two amino acids by dehydration synthesis.
19) The pH of body fluids must remain fairly constant for the body to maintain homeostasis.
20) Mixtures are combinations of elements or compounds that are physically blended together
but are not bound by chemical bonds.
21) Buffers resist abrupt and large changes in the pH of the body by releasing or binding ions.

Multiple-Choice Questions
1) Which of the following elements is necessary for proper conduction of nervous impulses?
A) Fe
B) I
C) P
D) Na
2) Choose the statement that is false or incorrect.
A) In chemical reactions, breaking old bonds requires energy and forming new bonds releases
energy.
B) Exergonic reactions release more energy than they absorb.
C) Endergonic reactions absorb more energy than they release.
D) A key feature of the bodys metabolism is the almost exclusive use of exergonic reactions by
the body.
3) In general, the lipids that we refer to as oils have ________.
A) a high water content
B) long fatty acid chains
C) a high degree of saturated bonds
D) a high degree of unsaturated bonds
4) The genetic information is coded in DNA by the ________.
A) regular alteration of sugar and phosphate molecules
B) sequence of the nucleotides
C) three-dimensional structure of the double helix
D) arrangement of the histones

5) Which of the following is not true of proteins?

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A) They may be denatured or coagulated by heat or acidity.

B) Some types are called enzymes.
C) They appear to be the molecular carriers of the coded hereditary information.
D) Their function depends on the three-dimensional shape.
6) The single most abundant protein in the body is ________.
A) DNA
B) hemoglobin
C) collagen
D) glucose
7) Carbohydrates are stored in the liver and muscles in the form of ________.
A) glucose
B) triglycerides
C) glycogen
D) cholesterol
8) Which of the following describes coenzymes?
A) organic molecules derived from vitamins
B) two enzymes that perform the same function
C) metal ions
D) enzymes that work together
9) Which of the following is not a role of molecular chaperonins?
A) prevent accidental, premature, or incorrect folding of polypeptide chains
B) aid the desired folding and association process of polypeptides
C) help to translocate proteins and certain metal ions across cell membranes
D) promote the breakdown of damaged or denatured proteins
E) act as a biological catalyst
10) A chemical reaction in which bonds are broken is usually associated with ________.
A) the release of energy
B) the consumption of energy
C) a synthesis
D) forming a larger molecule
11) Salts are always ________.
A) ionic compounds
B) single covalent compounds
C) double covalent compounds
D) hydrogen bonded
12) The numbers listed represent the number of electrons in the first, second, and third energy
levels, respectively. On this basis, which of the following is an unstable or reactive atom?
A) 2, 8, 8
B) 2, 8
C) 2
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D) 2, 8, 1
13) A solution that has a pH of 2 could best be described as being ________.
A) acidic
B) basic
C) neutral
D) slightly acidic
14) Which of the following is the major positive ion outside cells?
A) nitrogen
B) hydrogen
C) potassium
D) sodium
15) Which of the following would be regarded as an organic molecule?
A) H2O
B) NaCl
C) NaOH
D) CH4
16) What is a chain of 25 amino acids called?
A) polypeptide
B) nucleotide
C) protein
D) starch
17) Which of the following constitutes a long chain of simple sugars?
A) monosaccharide
B) polysaccharide
C) protein
D) nucleic acid
18) What level of protein synthesis is represented by the coiling of the protein chain backbone
into an alpha helix?
A) primary structure
B) secondary structure
C) tertiary structure
D) quaternary structure
19) Carbohydrates and proteins are built up from their basic building blocks by the ________.
A) addition of a water molecule between each two units
B) addition of a carbon atom between each two units
C) removal of a water molecule between each two units
D) removal of a nitrogen atom between each two units

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20) Which statement about enzymes is false?

A) Enzymes raise the activation energy needed to start a reaction.
B) Enzymes are composed mostly of protein.
C) Enzymes are organic catalysts.
D) Enzymes may be damaged by high temperature.
21) Which of the following statements is false?
A) Chemical reactions proceed more quickly at higher temperatures.
B) Chemical reactions progress at a faster rate when the reacting particles are present in higher
numbers.
C) Larger particles move faster than smaller ones and thus collide more frequently and more
forcefully.
D) Catalysts increase the rate of chemical reactions.
22) Which of the following is true regarding the concentration of solutions?
A) Percent solutions are parts per 1000 parts.
B) Molarity is one mole of solute per 1000 ml of solution.
C) To calculate molarity, one must know the atomic number of the solute.
D) To calculate molarity, one must know the atomic weight of the solvent.
23) Select the statement about mixtures that is correct.
A) A solution contains solvent in large amounts and solute in smaller quantities.
B) Solutions contain particles that settle out in time.
C) Suspensions can change reversibly from liquid to solid.
D) Suspensions are homogeneous mixtures of two or more components.
24) Choose the answer that best describes HCO3-.
A) a bicarbonate ion
B) common in the liver
C) a weak acid
D) a proton donor
25) Select which reactions will usually be irreversible regarding chemical equilibrium in living
systems.
A) glucose to CO2 and H2O
B) ADP + Pi to make ATP
C) H2O + CO2 to make H2CO3
D) glucose molecules joined to make glycogen
26) What happens in redox reactions?
A) electron exchange occurs
B) the electron acceptor is oxidized
C) the electron donor is reduced
D) the reaction is always easily reversible
27) Choose the answer that best describes fibrous proteins.
A) rarely exhibit secondary structure
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B) are very stable and insoluble in water

C) are usually called enzymes
D) are cellular catalysts
28) Which of the following does not describe the ATP molecule?
A) chemical work
B) mechanical work
C) transport
D) pigments
29) Select the most correct statement regarding nucleic acids.
A) Three forms exist: DNA, RNA, and tDNA.
B) DNA is a long, double-stranded molecule made up of A, T, G, and C bases.
C) RNA is a long, single-stranded molecule made up of the bases A, T, G, and C.
D) TDNA is considered a molecular slave of DNA.
30) Which of the following is an example of a suspension?
A) cytoplasm
B) salt water
C) rubbing alcohol
D) blood
Answer: D
Diff: 2
Page Ref: 29-30; Fig. 2.4
31) Select the correct statement about isotopes.
A) Isotopes of the same element have the same atomic number but differ in their atomic masses.
B) All the isotopes of an element have the same number of neutrons.
C) All the isotopes of an element are radioactive.
D) Isotopes occur only in the heavier elements.
32) The four elements that make up about 96% of body matter are ________.
A) carbon, oxygen, phosphorus, calcium
B) nitrogen, hydrogen, calcium, sodium
C) carbon, oxygen, hydrogen, nitrogen
D) sodium, potassium, hydrogen, oxygen
33) An example of a coenzyme is ________.
A) copper
B) riboflavin (vitamin B2)
C) iron
D) zinc
34) ________ is fat soluble, produced in the skin on exposure to UV radiation, and necessary for
normal bone growth and function.
A) Vitamin K
B) Cortisol
C) Vitamin A
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D) Vitamin D
35) In liquid XYZ, you notice that light is scattered as it passes through. There is no precipitant
in the bottom of the beaker, though it has been sitting for several days. What type of liquid is
this?
A) solution
B) suspension
C) colloid
D) mixture
36) Atom X has 17 protons. How many electrons are in its valence shell?
A) 3
B) 5
C) 7
D) 10
37) Which protein types are vitally important to cell function in all types of stressful
circumstances?
A) structural proteins
B) molecular chaperones
C) catalytic proteins
D) regulatory proteins
38) If atom X has an atomic number of 74 it would have which of the following?
A) 37 protons and 37 neutrons
B) 37 electrons
C) 74 protons
D) 37 protons and 37 electrons
39) What does the formula C6H12O6 mean?
A) There are 6 calcium, 12 hydrogen, and 6 oxygen atoms.
B) There are 12 hydrogen, 6 carbon, and 6 oxygen atoms.
C) The molecular weight is 24.
D) The substance is a colloid.
40) Two good examples of a colloid would be Jell-O and ________.
A) blood
B) toenails
C) urine
D) cytosol
41) An atom with a valence of 3 may have a total of ________ electrons.
A) 3
B) 8
C) 13
D) 17
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42) Which of the following is a neutralization reaction?

A) HCl H+ + ClB) NaOH Na+ + OHC) NH3 + H+ NH4+2
D) HCl + NaOH NaCl + H2O
43) The chemical symbol O=O means ________.
A) zero equals zero
B) both atoms are bonded and have zero electrons in the outer orbit
C) the atoms are double bonded
D) this is an ionic bond with two shared electrons
44) What is a dipole?
A) a type of bond
B) a polar molecule
C) a type of reaction
D) an organic molecule
45) What does CH4 mean?
A) There is one carbon and four hydrogen atoms.
B) There are four carbon and four hydrogen atoms.
C) This is an inorganic molecule.
D) This was involved in a redox reaction.
46) Amino acids joining together to make a peptide is a good example of a(n) ________ reaction.
A) synthesis
B) decomposition
C) exchange
D) reversible
47) Which of the following is not considered a factor in influencing a reaction?
A) temperature
B) concentration
C) particle size
D) time
48) Which of the following is not an electrolyte?
A) HCl
B) Ca2CO3
C) H2O
D) NaOH
49) Which property of water is demonstrated when we sweat?
A) high heat capacity
B) high heat of vaporization
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C) polar solvent properties

D) reactivity
E) cushioning
50) Sucrose is a ________.
A) monosaccharide
B) disaccharide
C) polysaccharide
D) triglyceride
51) What is the ratio of fatty acids to glycerol in neutral fats?
A) 1:1
B) 2:1
C) 3:1
D) 4:1
52) In a DNA molecule, the phosphate serves ________.
A) as a code
B) to hold the molecular backbone together
C) to bind the sugars to their bases
D) as nucleotides
53) Heat shock proteins (hsp) are a type of protein called ________.
A) coenzymes
B) cofactors
C) eicosanoids
D) chaperonins
54) Which bonds often bind different parts of a molecule into a specific three-dimensional
shape?
A) Carbon
B) Hydrogen
C) Oxygen
D) Amino acid
Fill-in-the-Blank/Short Answer Questions
1) The atomic number is equal to the number of ________.
2) Molecules such as methane that are made of atoms that share electrons have ________ bonds.
3) An atom with three electrons would have a valence of ________.
4) AB A + B is an example of a(n) ________ reaction.
5) ________ have a bitter taste, feel slippery, and are proton acceptors.
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6) A holoenzyme is composed of an apoenzyme and a(n) ________.

7) In a DNA molecule, guanine would connect to ________.
8) The ________ molecule directly provides energy for cellular work.
9) Hydrogen bonds are more like a type of weak ________ than true bonds.
10) Weak acids and bases make good ________.
11) Starch is the stored carbohydrate in plants, while ________ is the stored carbohydrate in
animals.
12) How many phosphates would AMP have attached to it?
13) Which metals have a toxic effect on the body?
14) What does the polar end of a phospholipid contain?
15) What type of chemical bond can form between an element with 11 protons and an element
with 17 protons?
16) What happens when globular proteins are denatured?
17) Explain the difference between potential and kinetic energy.
18) How can phospholipids form a film when mixed in water?
19) What properties does water have that make it a very versatile fluid?
20) What advantages does ATP have in being the energy currency molecule?
21) Explain why chemical reactions in the body are often irreversible.
22) When a set of electrodes connected to a lightbulb is placed in a solution of dextrose and a
current is applied, the lightbulb does not light up. When the same unit is placed in HCl, it does.
Why?

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23) Describe the factors that affect chemical reaction rates.

24) Protons and electrons exist in every atom nucleus except hydrogen. Is this statement true or
false and why?
25) A chemical bond never occurs in a mixture. Discuss this.
26) All chemical reactions are theoretically reversible. Comment on this statement.
27) What is the major difference between polar and nonpolar covalent bonds?
28) An amino acid may act as a proton acceptor or donor. Explain.
29) Name at least four things you know about enzymes.
Answer:
1. They are proteins.
2. They have specific binding sites for specific substrates.
3. They lower the activation barrier for a specific reaction.
4. The names end in "ase."
5. They can be denatured.
6. They can be used again and again.
30) In the compound H2CO3, what do the numbers 2 and 3 represent?
31) Are all chemical reactions reversible? If not, why arent they all reversible?
Clinical Questions
1) Mrs. Mulligan goes to her dentist and, after having a couple of cavities filled, her dentist
strongly suggests that she reduce her intake of sodas and increase her intake of calcium
phosphates in the foods she eats. Why?
2) Although his cholesterol levels were not high, Mr. Martinez read that cholesterol was bad for
his health, so he eliminated all foods and food products containing this molecule. He later found
that his cholesterol level dropped only 20%. Why did it not drop more?
3) How can DNA be used to "fingerprint" a suspect in a crime?
4) Why is it possible for us to drink a solution that contains a mixture of equal concentration of a
strong acid and a strong base, either of which, separately, would be very caustic?
5) A 65-year-old patient came to the emergency room with complaints of severe heartburn
unrelieved by taking a "large handful" of antacids. Would you expect the pH to be high or low?
Explain why.
6) A 23-year-old male was riding his road bike in 100-degree heat, when he suddenly became
nauseated and weak. He called 911 from his cell phone. When the ambulance came, the
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paramedics started intravenous therapy for severe dehydration. Explain the critical role of water
to maintain homeostasis.
7) Brenda is a 26-year-old female who is being discharged from the hospital after a vaginal
delivery of an 8-pound healthy infant. Brenda is instructed by the nurse to eat a diet high in fiber
and to drink 8 glasses of water per day to prevent constipation. Explain the role of fiber and
water to promote defecation.
Answer: Cellulose is a polysaccharide found in all plant products that adds bulk to the diet to
promote feces through the colon. Water acts as a lubricating liquid within the colon, which eases
feces through the bowel.
Diff: 3
Page Ref: 38-39, 43
8) A 64-year-old man is admitted to the hospital for nonhealing pressure ulcers to his heels. He
has been bedridden for 10 years because of a degenerative muscle disease. Explain why protein
would be an important part of his diet to promote wound healing.

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