TABLE OF CONTENTS

TABLE OF CONTENTS

I FOUNDATIONS
1. Embryology 3
2. Teratogenesis 5
3. Cell Biology: Organelles 7
4. Cell Biology: Cytoplasm and Cytoskeleton 10
5. Cell Biology: Plasma Membrane 12
6. Cellular Suffering and Death 16
7. Inflammation 18
8. Extracellular Environment 20
9. Cellular Adaptations 22
II NEUROLOGY
1. Organization of the Brain 26
2. Hypothalamus 28
3. Sleep 29
4. Cranial Nerves part 1 32
5. Cranial Nerves part 2 35
6. Brain Embryology 37
7. Regions of the Brain 39
8. Brainstem in Cross Section 42
9. Brainstem Lesions 46
10. Vascular Events 49
11. CSF 51
12. Headache 53
13. Brain Tumors 57
14. Anesthetics 59
15. Seizures 61
16. Movement 64
17. Basal Ganglia 70
18. Spinal Cord and Lesions 72
19. Brachial Plexus and Upper Extremity Nerves part 1 75
20. Brachial Plexus and Upper Extremity Nerves part 2 78
21. Lower Extremity and Skeletal Muscle 81
22. Sensation 84
23. Eye 86
24. Ear 88
25. Delirium and Dementia 91
III PHARM BASICS
1. Parasympathetic Activation 97
2. Parasympathetic Inhibition 100
3. Sympathetic Activation 102
4. Sympathetic Inhibition 104
5. Neurotransmission 106
6. G Protein Second Messengers 109
7. Pharmacokinetics 112
8. Pharmacodynamics 117
9. Drug Metabolism 119
10. Drug Elimination 121
11. Drug Side Effects 124
12. Antidotes 130

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IV CARDIOVASCULAR
1. Cardio Embryology 133
2. Developmental Pathology 136
3. Cardiac Output 138
4. Heart Failure 140
5. Treatment of CHF 142
6. Edema and Shock 144
7. Cardiac Cycle 147
8. Diastolic Heart Murmurs 149
9. Systolic Heart Murmurs 151
10. Electrophysiology 153
11. Antiarrhythmics 154
12. Electrocardiography 156
13. Arrhythmias 158
14. Regulation of BP 163
15. Hypertension 165
16. Antihypertensives 167
17. Atherosclerosis 170
18. Antianginal Therapy and Lipid-Lowering Agents 173
19. Myocardial Infarction part 1 175
20. Myocardial Infarction part 2 178
21. Cardiomyopathies and Endocarditis 180
22. Other Cardiac Pathology 182
23. Vascular Diseases 184
V RHEUM & DERM
1. Bone Formation and Bone Tumors 189
2. Bone Disorders 191
3. Joint Basics 194
4. Osteoarthritis and Rheumatoid Arthritis 197
5. Other Types of Arthritis 199
6. Systemic Disorders 201
7. Dermatology part 1 203
8. Dermatology part 2 206
VI REPRODUCTION
1. Anatomy and Embryology 211
2. Androgens 213
3. Testicular Pathology 214
4. Penis and Prostate Pathology 216
5. Female Reproductive Cycle 219
6. Birth Control and Menopause 221
7. Vaginal and Cervical Pathology 223
8. Uterine Pathology 225
9. Ovarian Disorders 227
10. Ovarian Tumors 229
11. Pregnancy part 1 231
12. Pregnancy part 2 234
13. Pregnancy part 3 236
14. Chromosomal Disorders 239
15. Genetic Disorders: AD and Trinucleotide Repeats 241
16. Genetic Disorders: AR and X-Linked 243
17. Breast 245

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VII MICRO
1. Bacterial Basics 251
2. Bacterial Toxins 253
3. Staphylococcus 255
4. Streptococcus 257
5. Other Gram Positive Bacteria 259
6. Intro to Gram Negative Bacteria 261
7. Diarrhea 263
8. UTI 266
9. Spirochetes and Zoonotics 268
10. Mycobacteria 270
11. Nonstaining Bacteria 272
12. Penicillins 274
13. Cephalosporins 276
14. Other Cell Wall Inhibitors 278
15. Protein Synthesis Inhibitors 280
16. Other Antibiotics 283
17. Micro by Systems part 1 288
18. Micro by Systems part 2 291
19. Viral Basics 293
20. DNA Viruses part 1 295
21. DNA Viruses part 2 297
22. RNA Viruses part 1 299
23. RNA Viruses part 2 301
24. HIV 304
25. HIV Drugs 306
26. Mycology part 1 308
27. Mycology part 2 310
28. Antifungals 312
29. Protozoa 314
30. Helminths and Ectoparasites 316
VIII IMMUNOLOGY
1. Immune System Basics 321
2. Antigen Presentation 322
3. T Cells 324
4. B Cells and Antibodies 325
5. Immunization and Autoantibodies 327
6. Hypersensitivity and Complement 329
7. Macrophages, Granulocytes and Cytokines 331
8. Immunosuppressants 333
9. Immunodeficiencies 335

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IX GI
1. Oropharynx 343
2. Esophagus 345
3. Stomach 348
4. Upper GI Path 350
5. Duodenum 352
6. Enterocytes and Absorption 354
7. Diseases of Small Intestine 356
8. Large Intestine part 1 358
9. Large Intestine part 2 360
10. Large Intestine part 3 362
11. Pancreas 364
12. Liver Basics 366
13. Alcoholic Liver Disease and Cirrhosis 368
14. Liver Pathology 370
15. Hepatitis 372
16. Biliary Tract 373
X PULMONARY
1. Anatomy and Physiology 379
2. Lung Volumes and Pulmonary Circulation 381
3. Oxygen and Hemoglobin 384
4. Oxygenation 386
5. Ventilation and Perfusion 388
6. Extreme Environments 389
7. PE, DVT, and Pneumothorax 392
8. COPD and Asthma 394
9. Pulmonary Medications 396
10. Restrictive Lung Disease 398
11. Lung Cancer 401
12. Lung Infections 403
XI MEDICINE IN SOCIETY
1. Research Study Designs 409
2. Diagnostic Test Evaluation 410
3. Interpretation of Study Data 412
4. Study Validity 414
5. Statistical Distribution and Error 416
6. Biostatistics 418
7. Public Health, Grief, and Geriatrics 420
8. Healthcare System 423
9. Ethics 429

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XII BIOCHEM
1. DNA Basics 433
2. DNA Replication, Mutation, and Repair 435
3. RNA 437
4. Protein Synthesis 441
5. Inheritance 442
6. Genetic Lab Techniques 445
7. Glycolysis 448
8. Gluconeogenesis 452
9. Glycogen 455
10. Energy Metabolism 457
11. HMP Shunt and Other Sugars 460
12. Starvation and Malnutrition 462
13. Lipids 465
14. Amino Acids and Nitrogen 468
15. Amino Acid Disorders 470
16. Minerals 472
17. Fat Soluble Vitamins and Antioxidants 474
18. Water Soluble Vitamins 476
XIII PSYCH
1. Psychology 481
2. Child Psych 483
3. Adolescent Psych 486
4. Alcohol Abuse 488
5. Substance Abuse 491
6. Psychosis 493
7. Antipsychotics 494
8. Bipolar Disorder 496
9. Depression 498
10. Antidepressants 500
11. Anxiety and Somatoform Disorders 502
12. Ego Defense Mechanisms and Personality Disorders 504
XIV RENAL
1. Renal Embryology and Anatomy 509
2. Glomerular Physiology 511
3. Nephron Physiology 513
4. Diuretics 518
5. Electrolyte Disorders 520
6. Acid-Base Disorders 522
7. Nephrosis and Nephritis 524
8. Other Renal Pathology 526
XV PEDIATRICS
1. Pediatric Review 530

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XVI ENDOCRINE
1. Endocrine Overview 536
2. Pituitary 538
3. Adrenal Steroid Synthesis 540
4. Glucocorticoids and Cushing Syndrome 543
5. Other Adrenal Pathology 545
6. Thyroid Basics and Hyperthyroidism 547
7. Hypothyroidism and Thyroid Cancer 549
8. Diabetes 551
9. DKA and Diabetes Treatment 552
10. Obesity 556
11. Calcium Metabolism 558
XVII HEME
1. Clotting Factors 563
2. Anticoagulant Drugs 564
3. RBC Basics 566
4. Erythropoiesis 568
5. Nonhemolytic Anemias 570
6. Hemolytic Anemias 572
7. Platelet Function 575
8. Platelet Disorders 577
9. Lymphoma 579
10. Leukemia and Multiple Myeloma 581
XVIII ONCOLOGY
1. Genetics of Cancer 587
2. Cancer Risk Factors 590
3. Tumor Nomenclature 592
4. Neoplastic Progression 594
5. Cancer Prevention and Host Defense 596
6. Cancer Drugs part 1 599
7. Cancer Drugs part 2 601

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 NOTES
NOTES

KEY TO ABBREVIATIONS
This Study Guide contains page references to several medical educational resources.
Below is a key to the abbreviations that accompany the various page number references
appearing in this text.

Le, T, Bhushan, V, et al. First Aid for the USMLE Step 1 2014.
FA14 New York, NY: McGraw-Hill; 2013.

Le, T, Bhushan, V, et al. First Aid for the USMLE Step 1 2013.
FA13 New York, NY: McGraw-Hill; 2012.

Jenkins, B, et al. Step-Up to USMLE Step 1 2014. Philadelphia, PA:

Hall, JE. Guyton and Hall Textbook of Medical Physiology. 12th ed.
Phys Philadelphia, PA: Saunders Elsevier; 2011.

Kumar, V, Abbas, AK, et al. Robbins and Cotran Pathologic Basis of

Moore, KL, Dalley, AF, & Agur, AMR. Clinically Oriented

Longo, DL, Fauci, AS, Kasper, DL, Hauser, SL, Jameson, JL,
H Loscalzo, J, eds. Harrison’s Principles of Internal Medicine. Vol. 2.
18th ed. New York, NY: McGraw-Hill; 2012.

Brunton, LL, Chabner, BA, & Knollman, BC, eds. Goodman &
GG Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York,
NY: McGraw-Hill; 2011.

COURSE VIEWING OPTIONS

No. of Videos/Day Video Runtime/Day*

15-day plan 16 Approx. 5.5 hrs

18-day plan 13 Approx. 4.5 hrs

21-day plan 11 Approx. 4 hrs

24-day plan 10 Approx. 3.5 hrs

30-day plan 8 Approx. 2.5 hrs

*Does not include study breaks or time spent annotating and answering questions. [ vii ]