Gate Syllabus For Engineering
Gate Syllabus For Engineering
Linear Algebra: Matrices and determinants; Systems of linear equations; Eigen values and Eigen
vectors.
Calculus: Limits, continuity and differentiability; Partial derivatives, maxima and minima;
Sequences and series; Test for convergence.
Differential Equations: Linear and nonlinear first order ODEs, higher order ODEs with constant
coefficients; Cauchy’s and Euler’s equations; Laplace transforms.
Probability and Statistics: Mean, median, mode and standard deviation; Random variables;
Poisson, normal and binomial distributions; Correlation and regression analysis.
Immunology: Innate and adaptive immunity, humoral and cell mediated immunity; Antibody
structure and function; Molecular basis of antibody diversity; T cell and B cell development;
Antigen-antibody reaction; Complement; Primary and secondary lymphoid organs; Major
histocompatibility complex (MHC); Antigen processing and presentation; Polyclonal and
monoclonal antibody; Regulation of immune response; Immune tolerance; Hypersensitivity;
Autoimmunity; Graft versus host reaction; Immunization and vaccines.
Section 3: Genetics, Cellular and Molecular Biology
Cell Biology: Prokaryotic and eukaryotic cell structure; Cell cycle and cell growth control; Cell-
cell communication; Cell signalling and signal transduction; Post-translational modifications;
Protein trafficking; Cell death and autophagy; Extra-cellular matrix.
Molecular Biology: Molecular structure of genes and chromosomes; Mutations and mutagenesis;
Regulation of gene expression; Nucleic acid - replication, transcription, splicing, translation and
their regulatory mechanisms; Non-coding and micro RNA; RNA interference; DNA damage and
repair.
Transport Processes: Newtonian and non-Newtonian fluids, fluid flow - laminar and turbulent;
Mixing in bioreactors, mixing time; Molecular diffusion and film theory; Oxygen transfer and
uptake in bioreactor, kLa and its measurement; Conductive and convective heat transfer, LMTD,
overall heat transfer coefficient; Heat exchangers.
Bioreaction Engineering: Rate law, zero and first order kinetics; Ideal reactors - batch, mixed
flow and plug flow; Enzyme immobilization, diffusion effects - Thiele modulus, effectiveness
factor, Damkoehler number; Kinetics of cell growth, substrate utilization and product formation;
Structured and unstructured models; Batch, fed-batch and continuous processes; Microbial and
enzyme reactors; Optimization and scale up.
Upstream and Downstream Processing: Media formulation and optimization; Sterilization of air
and media; Filtration - membrane filtration, ultra filtration; Centrifugation - high speed and ultra;
Cell disruption; Principles of chromatography - ion exchange, gel filtration, hydrophobic
interaction, affinity, GC, HPLC and FPLC; Extraction, adsorption and drying.
Instrumentation and Process Control: Pressure, temperature and flow measurement devices;
Valves; First order and second order systems; Feedback and feed forward control; Types of
controllers – proportional, derivative and integral control, tuning of controllers.
Plants: Totipotency; Regeneration of plants; Plant growth regulators and elicitors; Tissue culture
and cell suspension culture system - methodology, kinetics of growth and nutrient optimization;
Production of secondary metabolites; Hairy root culture; Plant products of industrial importance;
Artificial seeds; Somaclonal variation; Protoplast, protoplast fusion - somatic hybrid and cybrid;
Transgenic plants - direct and indirect methods of gene transfer techniques; Selection marker and
reporter gene; Plastid transformation.
Animals: Culture media composition and growth conditions; Animal cell and tissue preservation;
Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; Micro & macro-
carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic
animals; Knock-out and knock-in animals.
Molecular tools: Polymerase chain reaction; DNA/RNA labelling and sequencing; Southern and
northern blotting; In-situ hybridization; DNA fingerprinting, RAPD, RFLP; Site-directed
mutagenesis; Gene transfer technologies; CRISPR-Cas; Biosensing and biosensors.
Analytical tools: Principles of microscopy - light, electron, fluorescent and confocal; Principles
of spectroscopy - UV, visible, CD, IR, fluorescence, FT-IR, MS, NMR; Electrophoresis; Micro-
arrays; Enzymatic assays; Immunoassays - ELISA, RIA, immunohistochemistry;
immunoblotting; Flow cytometry; Whole genome and ChIP sequencing.
Computational tools: Bioinformatics resources and search tools; Sequence and structure
databases; Sequence analysis - sequence file formats, scoring matrices, alignment, phylogeny;
Genomics, proteomics, metabolomics; Gene prediction; Functional annotation; Secondary
structure and 3D structure prediction; Knowledge discovery in biochemical databases;
Metagenomics; Metabolic engineering and systems biology.
CE Civil Engineering
Section 1: Engineering Mathematics
Linear Algebra: Matrix algebra; Systems of linear equations; eigen values and eigen vectors.
Calculus: Functions of single variable; Limit, continuity and differentiability; Mean value
theorems, local maxima and minima; Taylor series; Evaluation of definite and indefinite
integrals, application of definite integral to obtain area and volume; Partial derivatives; Total
derivative; Gradient, Divergence and Curl, Vector identities; Directional derivatives; Line,
Surface and Volume integrals.
Ordinary Differential Equation (ODE): First order (linear and non-linear) equations; higher order
linear equations with constant coefficients; Euler-Cauchy equations; initial and boundary value
problems.
Partial Differential Equation (PDE): Fourier series; Separation of variables; solutions of one-
dimensional diffusion equation; first and second order one-dimensional wave equation and two-
dimensional Laplace equation.
Numerical Methods: Error analysis. Numerical solutions of linear and non-linear algebraic
equations; Newton’s and Lagrange polynomials; numerical differentiation; Integration by
trapezoidal and Simpson’s rule; Single and multi-step methods for first order differential
equations.
Solid Mechanics: Bending moment and shear force in statically determinate beams; Simple stress
and strain relationships; Simple bending theory, flexural and shear stresses, shear centre;
Uniform torsion, Transformation of stress; buckling of column, combined and direct bending
stresses.
Concrete Structures: Working stress and Limit state design concepts; Design of beams, slabs,
columns; Bond and development length; Prestressed concrete beams.
Steel Structures: Working stress and Limit state design concepts; Design of tension and
compression members, beams and beam- columns, column bases; Connections - simple and
eccentric, beam-column connections, plate girders and trusses; Concept of plastic analysis -
beams and frames.
Soil Mechanics: Three-phase system and phase relationships, index properties; Unified and
Indian standard soil classification system; Permeability - one dimensional flow, Seepage through
soils – two - dimensional flow, flow nets, uplift pressure, piping, capillarity, seepage force;
Principle of effective stress and quicksand condition; Compaction of soils; One- dimensional
consolidation, time rate of consolidation; Shear Strength, Mohr’s circle, effective and total shear
strength parameters, Stress-Strain characteristics of clays and sand; Stress paths.
Foundation Engineering: Sub-surface investigations - Drilling bore holes, sampling, plate load
test, standard penetration and cone penetration tests; Earth pressure theories - Rankine and
Coulomb; Stability of slopes – Finite and infinite slopes, Bishop’s method; Stress distribution in
soils – Boussinesq’s theory; Pressure bulbs, Shallow foundations – Terzaghi’s and Meyerhoff’s
bearing capacity theories, effect of water table; Combined footing and raft foundation; Contact
pressure; Settlement analysis in sands and clays; Deep foundations – dynamic and static
formulae, Axial load capacity of piles in sands and clays, pile load test, pile under lateral loading,
pile group efficiency, negative skin friction.
Fluid Mechanics: Properties of fluids, fluid statics; Continuity, momentum and energy equations
and their applications; Potential flow, Laminar and turbulent flow; Flow in pipes, pipe networks;
Concept of boundary layer and its growth; Concept of lift and drag.
Hydraulics: Forces on immersed bodies; Flow measurement in channels and pipes; Dimensional
analysis and hydraulic similitude; Channel Hydraulics - Energy-depth relationships, specific
energy, critical flow, hydraulic jump, uniform flow, gradually varied flow and water surface
profiles.
Irrigation: Types of irrigation systems and methods; Crop water requirements - Duty, delta,
evapo- transpiration; Gravity Dams and Spillways; Lined and unlined canals, Design of weirs on
permeable foundation; cross drainage structures.
Water and Waste Water Quality and Treatment: Basics of water quality standards – Physical,
chemical and biological parameters; Water quality index; Unit processes and operations; Water
requirement; Water distribution system; Drinking water treatment.
Sewerage system design, quantity of domestic wastewater, primary and secondary treatment.
Effluent discharge standards; Sludge disposal; Reuse of treated sewage for different applications.
Air Pollution: Types of pollutants, their sources and impacts, air pollution control, air quality
standards, Air quality Index and limits.
Concept of airport runway length, calculations and corrections; taxiway and exit taxiway design.
Highway Pavements: Highway materials - desirable properties and tests; Desirable properties of
bituminous paving mixes; Design factors for flexible and rigid pavements; Design of flexible and
rigid pavement using IRC codes.
Traffic Engineering: Traffic studies on flow and speed, peak hour factor, accident study,
statistical analysis of traffic data; Microscopic and macroscopic parameters of traffic flow,
fundamental relationships; Traffic signs; Signal design by Webster’s method; Types of
intersections; Highway capacity.
Principles of surveying; Errors and their adjustment; Maps - scale, coordinate system; Distance
and angle measurement - Levelling and trigonometric levelling; Traversing and triangulation
survey; Total station; Horizontal and vertical curves.
Photogrammetry and Remote Sensing - Scale, flying height; Basics of remote sensing and GIS.
CH Chemical Engineering
Section 1: Engineering Mathematics
Linear Algebra: Matrix algebra, Systems of linear equations, Eigen values and eigenvectors.
Calculus: Functions of single variable, Limit, continuity and differentiability, Taylor series,
Mean value theorems, Evaluation of definite and improper integrals, Partial derivatives, Total
derivative, Maxima and minima, Gradient, Divergence and Curl, Vector identities, Directional
derivatives, Line, Surface and Volume integrals, Stokes, Gauss and Green’s theorems.
Differential Equations: First order equations (linear and nonlinear), Higher order linear
differential equations with constant coefficients, Cauchy’s and Euler’s equations, Initial and
boundary value problems, Laplace transforms, Solutions of one-dimensional heat and wave
equations and Laplace equation.
Complex Variables: Complex number, polar form of complex number, triangle inequality.
Steady and unsteady state mass and energy balances including multiphase, multi-component,
reacting and non-reacting systems. Use of tie components; recycle, bypass and purge
calculations; Gibb’s phase rule and degree of freedom analysis.
First and Second laws of thermodynamics. Applications of first law to close and open systems.
Second law and Entropy. Thermodynamic properties of pure substances: Equation of State and
residual properties, properties of mixtures: partial molar properties, fugacity, excess properties
and activity coefficients; phase equilibria: predicting VLE of systems; chemical reaction
equilibrium.
Fluid statics, surface tension, Newtonian and non-Newtonian fluids, transport properties, shell-
balances including differential form of Bernoulli equation and energy balance, equation of
continuity, equation of motion, equation of mechanical energy, Macroscopic friction factors,
dimensional analysis and similitude, flow through pipeline systems, velocity profiles, flow
meters, pumps and compressors, elementary boundary layer theory, flow past immersed bodies
including
packed and fluidized beds, Turbulent flow: fluctuating velocity, universal velocity profile and
pressure drop.
Particle size and shape, particle size distribution, size reduction and classification of solid
particles; free and hindered settling; centrifuge and cyclones; thickening and classification,
filtration, agitation and mixing; conveying of solids.
Equation of energy, steady and unsteady heat conduction, convection and radiation, thermal
boundary layer and heat transfer coefficients, boiling, condensation and evaporation; types of
heat exchangers and evaporators and their process calculations; design of double pipe, shell and
tube heat exchangers, and single and multiple effect evaporators.
Fick’s laws, molecular diffusion in fluids, mass transfer coefficients, film, penetration and
surface renewal theories; momentum, heat and mass transfer analogies; stage-wise and
continuous contacting and stage efficiencies; HTU & NTU concepts; design and operation of
equipment for distillation, absorption, leaching, liquid-liquid extraction, drying, humidification,
dehumidification and adsorption, membrane separations (micro-filtration, ultra-filtration, nano-
filtration and reverse osmosis).
Measurement of process variables; sensors and transducers; P&ID equipment symbols; process
modeling and linearization, transfer functions and dynamic responses of various systems,
systems with inverse response, process reaction curve, controller modes (P, PI, and PID); control
valves; transducer dynamics; analysis of closed loop systems including stability, frequency
response, controller tuning, cascade and feed forward control.
Principles of process economics and cost estimation including depreciation and total annualized
cost, cost indices, rate of return, payback period, discounted cash flow, optimization in process
design and sizing of chemical engineering equipments such as heat exchangers and multistage
contactors.
Section 9: Chemical Technology
Inorganic chemical industries (sulfuric acid, phosphoric acid, chlor-alkali industry), fertilizers
(Ammonia, Urea, SSP and TSP); natural products industries (Pulp and Paper, Sugar, Oil, and
Fats); petroleum refining and petrochemicals; polymerization industries (polyethylene,
polypropylene, PVC and polyester synthetic fibers).
CS Computer Science and Information Technology
Section 1: Engineering Mathematics
Discrete Mathematics: Propositional and first order logic. Sets, relations, functions, partial orders and
lattices. Monoids, Groups. Graphs: connectivity, matching, colouring. Combinatorics: counting,
recurrence relations, generating functions.
Linear Algebra: Matrices, determinants, system of linear equations, eigenvalues and eigenvectors, LU
decomposition.
Calculus: Limits, continuity and differentiability, Maxima and minima, Mean value theorem, Integration.
Probability and Statistics: Random variables, Uniform, normal, exponential, Poisson and binomial
distributions. Mean, median, mode and standard deviation. Conditional probability and Bayes theorem.
Section 5: Algorithms
Searching, sorting, hashing. Asymptotic worst case time and space complexity. Algorithm design
techniques: greedy, dynamic programming and divide‐and‐conquer. Graph traversals, minimum spanning
trees, shortest paths.
Section 9: Databases
ER‐model. Relational model: relational algebra, tuple calculus, SQL. Integrity constraints, normal forms.
File organization, indexing (e.g., B and B+ trees). Transactions and concurrency control.
Linear Algebra: Vector space, basis, linear dependence and independence, matrix algebra, eigen
values and eigen vectors, rank, solution of linear equations - existence and uniqueness.
Calculus: Mean value theorems, theorems of integral calculus, evaluation of definite and
improper integrals, partial derivatives, maxima and minima, multiple integrals, line, surface and
volume integrals, Taylor series.
Differential Equations: First order equations (linear and nonlinear), higher order linear
differential equations, Cauchy's and Euler's equations, methods of solution using variation of
parameters, complementary function and particular integral, partial differential equations,
variable separable method, initial and boundary value problems.
Vector Analysis: Vectors in plane and space, vector operations, gradient, divergence and curl,
Gauss's, Green's and Stokes’ theorems.
Complex Analysis: Analytic functions, Cauchy’s integral theorem, Cauchy’s integral formula,
sequences, series, convergence tests, Taylor and Laurent series, residue theorem.
Probability and Statistics: Mean, median, mode, standard deviation, combinatorial probability,
probability distributions, binomial distribution, Poisson distribution, exponential distribution,
normal distribution, joint and conditional probability.
Circuit Analysis: Node and mesh analysis, superposition, Thevenin's theorem, Norton’s theorem,
reciprocity. Sinusoidal steady state analysis: phasors, complex power, maximum power transfer.
Time and frequency domain analysis of linear circuits: RL, RC and RLC circuits, solution of
network equations using Laplace transform.
Continuous-time Signals: Fourier series and Fourier transform, sampling theorem and
applications.
Energy bands in intrinsic and extrinsic semiconductors, equilibrium carrier concentration, direct
and indirect band-gap semiconductors.
Carrier Transport: Diffusion current, drift current, mobility and resistivity, generation and
recombination of carriers, Poisson and continuity equations.
P-N junction, Zener diode, BJT, MOS capacitor, MOSFET, LED, photo diode and solar cell.
BJT and MOSFET Amplifiers: Biasing, AC coupling, small signal analysis, frequency response.
Current mirrors and differential amplifiers.
Sequential Circuits: Latches and flip-flops, counters, shift-registers, finite state machines,
propagation delay, setup and hold time, critical path delay.
Computer Organization: Machine instructions and addressing modes, ALU, data-path and control
unit, instruction pipelining.
Basic control system components; Feedback principle; Transfer function; Block diagram
representation; Signal flow graph; Transient and steady-state analysis of LTI systems; Frequency
response; Routh-Hurwitz and Nyquist stability criteria; Bode and root-locus plots; Lag, lead and
lag-lead compensation; State variable model and solution of state equation of LTI systems.
Section 7: Communications
Random Processes: Auto correlation and power spectral density, properties of white noise,
filtering of random signals through LTI systems.
Digital Communications: PCM, DPCM, digital modulation schemes (ASK, PSK, FSK, QAM),
bandwidth, inter-symbol interference, MAP, ML detection, matched filter receiver, SNR and
BER. Fundamentals of error correction, Hamming codes, CRC.
Section 8: Electromagnetics
Maxwell's Equations: Differential and integral forms and their interpretation, boundary
conditions, wave equation, Poynting vector.
Plane Waves and Properties: Reflection and refraction, polarization, phase and group velocity,
propagation through various media, skin depth.
Representation of continuous and discrete time signals, shifting and scaling properties, linear
time invariant and causal systems, Fourier series representation of continuous and discrete time
periodic signals, sampling theorem, Applications of Fourier Transform for continuous and
discrete time signals, Laplace Transform and Z transform. R.M.S. value, average value
calculation for any general periodic waveform.
Section 5: Electrical Machines
Single phase transformer: equivalent circuit, phasor diagram, open circuit and short circuit tests,
regulation and efficiency; Three-phase transformers: connections, vector groups, parallel
operation; Auto-transformer, Electromechanical energy conversion principles; DC machines:
separately excited, series and shunt, motoring and generating mode of operation and their
characteristics, speed control of dc motors; Three-phase induction machines: principle of
operation, types, performance, torque-speed characteristics, no-load and blocked-rotor tests,
equivalent circuit, starting and speed control; Operating principle of single-phase induction
motors; Synchronous machines: cylindrical and salient pole machines, performance and
characteristics, regulation and parallel operation of generators, starting of synchronous motors;
Types of losses and efficiency calculations of electric machines.
Basic concepts of electrical power generation, AC and DC transmission concepts, Models and
performance of transmission lines and cables, Economic Load Dispatch (with and without
considering transmission losses), Series and shunt compensation, Electric field distribution and
insulators, Distribution systems, Per‐unit quantities, Bus admittance matrix, Gauss- Seidel and
Newton-Raphson load flow methods, Voltage and Frequency control, Power factor correction,
Symmetrical components, Symmetrical and unsymmetrical fault analysis, Principles of over‐
current, differential, directional and distance protection; Circuit breakers, System stability
concepts, Equal area criterion.
Bridges and Potentiometers, Measurement of voltage, current, power, energy and power factor;
Instrument transformers, Digital voltmeters and multi-meters, Phase, Time and Frequency
measurement; Oscilloscopes, Error analysis.
Simple diode circuits: clipping, clamping, rectifiers; Amplifiers: biasing, equivalent circuit and
frequency response; oscillators and feedback amplifiers; operational amplifiers: characteristics
and applications; single stage active filters, Active Filters: Sallen Key, Butterwoth, VCOs and
timers,
combinatorial and sequential logic circuits, multiplexers, demultiplexers, Schmitt triggers,
sample and hold circuits, A/D and D/A converters.
Static V-I characteristics and firing/gating circuits for Thyristor, MOSFET, IGBT; DC to DC
conversion: Buck, Boost and Buck-Boost Converters; Single and three-phase configuration of
uncontrolled rectifiers; Voltage and Current commutated Thyristor based converters;
Bidirectional ac to dc voltage source converters; Magnitude and Phase of line current harmonics
for uncontrolled and thyristor based converters; Power factor and Distortion Factor of AC to DC
converters; Single- phase and three-phase voltage and current source inverters, sinusoidal pulse
width modulation.
XE-G Food Technology
Section 1: Food Chemistry and Nutrition
Carbohydrates: Structure and functional properties of mono-, oligo-, & poly- saccharides
including starch, cellulose, pectic substances and dietary fibre, gelatinization and retrogradation of
starch.
Proteins: classification and structure of proteins in food, biochemical changes in post mortem and
tenderization of muscles.
Food Flavours: Terpenes, esters, aldehydes, ketones and quinines. Enzymes: specificity, simple
and inhibition kinetics, coenzymes, enzymatic and non- enzymatic browning.
Nutrition: Balanced diet, essential amino acids and essential fatty acids, protein efficiency ratio,
water soluble and fat soluble vitamins, role of minerals in nutrition, co-factors, anti-nutrients,
nutraceuticals, nutrient deficiency diseases.
Chemical and Biochemical Changes: Changes occurring in foods during different processing.
Food Spoilage: Spoilage microorganisms in different food products including milk, fish, meat,
egg, cereals and their products.
Fermented Foods and Beverages: Curd, yoghurt, cheese, pickles, soya-sauce, sauerkraut, idli, dosa,
vinegar, alcoholic beverages and sausage.
Fruits and Vegetables Processing: Extraction, clarification, concentration and packaging of fruit
juice, jam, jelly, marmalade, squash, candies, tomato sauce, ketchup, and puree, potato chips,
pickles.
Plantation crops processing and products: Tea, coffee, cocoa, spice, extraction of essential oils
and oleoresins from spices.
Milk and Milk Products Processing: Pasteurization and sterilization, cream, butter, ghee, ice-
cream, cheese and milk powder. Processing of animal products: drying, canning, and freezing of
fish and meat; production of egg powder.
Waste Utilization: Pectin from fruit wastes, uses of by-products from rice milling.
Food standards and Quality Maintenance: FPO, PFA, A-Mark, ISI, HACCP, food plant
sanitation and cleaning in place (CIP).
Momentum Transfer: Flow rate and pressure drop relationships for Newtonian fluids flowing
through pipe, Reynolds number. Heat transfer: heat transfer by conduction, convection, radiation,
heat exchangers.
Mass Transfer: Molecular diffusion and Flick's law, conduction and convective mass transfer,
permeability through single and multilayer films.
Group theory: Symmetry elements and operations; Point groups and character tables;
Internal coordinates and vibrational modes; symmetry adapted linear combination of atomic
orbitals (LCAO-MO); construction of hybrid orbitals using symmetry aspects.
Kinetics (Topic has been rearranged): Elementary, parallel, opposing and consecutive
reactions. Steady state approximation. Mechanisms of complex reactions. Unimolecular
reactions. Potential energy surfaces and classical trajectories, Concept of Saddle points,
Transition state theory: Eyring equation, thermodynamic aspects. Kinetics of polymerization.
Catalysis concepts and enzyme catalysis. Kinetic isotope effects. Fast reaction kinetics:
relaxation and flow methods. Diffusion controlled reactions. Kinetics of photochemical and
photo physical processes.
Surfaces and Interfaces: Physisorption and chemisorption. Langmuir, Freundlich and
Brunauer–Emmett–Teller (BET) isotherms. Surface catalysis: Langmuir-Hinshelwood
mechanism. Surface tension, viscosity. Self-assembly. Physical chemistry of colloids,
micelles and macromolecules.
Main Group Elements: Hydrides, halides, oxides, oxoacids, nitrides, sulfides – shapes and
reactivity. Structure and bonding of boranes, carboranes, silicones, silicates, boron nitride,
borazines and phosphazenes. Allotropes of carbon, phosphorous and sulphur. Industrial
synthesis of compounds of main group elements. Chemistry of noble gases,
pseudohalogens, and interhalogen compounds. Acid-base concepts and principles (Lewis,
Brønsted, HSAB and acid-base catalysis).
Lanthanides and Actinides: Recovery. Periodic properties, spectra and magnetic properties.
Bioinorganic Chemistry: Ion (Na+ and K+) transport, oxygen binding, transport and utilization,
electron transfer reactions, nitrogen fixation, metalloenzymes containing magnesium,
molybdenum, iron, cobalt, copper and zinc.
Solids: Crystal systems and lattices, Miller planes, crystal packing, crystal defects, Bragg’s
law, ionic crystals, structures of AX, AX2, ABX3 type compounds, spinels, band theory,
metals and semiconductors.
Stereochemistry: Chirality and symmetry of organic molecules with or without chiral centres
and determination of their absolute configurations. Relative stereochemistry in compounds
having more than one stereogenic centre. Homotopic, enantiotopic and diastereotopic
atoms, groups and faces. Stereoselective and stereospecific synthesis. Conformational
analysis of acyclic and cyclic compounds. Geometrical isomerism and optical isomerism.
Configurational and conformational effects, atropisomerism, and neighbouring group
participation on reactivity and selectivity/specificity.
Organic Synthesis: Synthesis, reactions, mechanisms and selectivity involving the following
classes of compounds – alkenes, alkynes, arenes, alcohols, phenols, aldehydes, ketones,
carboxylic acids, esters, nitriles, halides, nitro compounds, amines and amides. Uses of Mg,
Li, Cu, B, Zn, P, S, Sn and Si based reagents in organic synthesis. Carbon-carbon bond
formation through coupling reactions - Heck, Suzuki, Stille, Sonogoshira, Negishi, Kumada,
Hiyama, Tsuji-Trost, olefin metathesis and McMurry. Concepts of multistep synthesis -
retrosynthetic analysis, strategic disconnections, synthons and synthetic equivalents. Atom
economy and Green Chemistry, Umpolung reactivity – formyl and acyl anion equivalents.
Selectivity in organic synthesis – chemo-, regio- and stereoselectivity. Protection and
deprotection of functional groups. Concepts of asymmetric synthesis – resolution (including
enzymatic), desymmetrization and use of chiral auxiliaries, organocatalysis. Carbon-carbon
and carbon-heteroatom bond forming reactions through enolates (including boron enolates),
enamines and silyl enol ethers. Stereoselective addition to C=O groups (Cram, Prelog and
Felkin-Anh models).