MHC questions and answers
1) T cells recognise antigen
a) In a 3 dimensional form
b) In solution in the plasma
✓ c) When presented on the surface of antigen presenting cells
d) Following presentation by pattern recognition receptors
2) CD4 T cells are generally restricted by
a) CD-1
b) MHC class -I
✓ c) MHC class-II
d) β2 microglobulin
3) MHC class I molecules are primarily involved in
a) Recognition of glycolipid antigens
b) Resistance to fungi
✓ c) Resistance to viruses
d) Activation of neutrophils
4) costimulatory molecules help T cell responses by
a) Increasing T cell activation in an antigen specific manner
✓ b) Increasing T cell activation regardless of the specificity of the T cell
c) Degrading antigen so it can bind in the MHC groove
d) Binding to MHC molecules containing immunogenic peptides
5) Activation of naïve T lymphocytes is best achieved by which antigen presenting cells?
a) Macrophages
b) Neutrophils
c) Mast cells
✓ d) Dendritic cells
6) Major Histocompatibility Complex is a tight cluster of linked___________
a) Carbohydrates
b) Proteins
c) Genes
d) Lipid molecules
7) What is the name of MHC in humans?
a) HLA
b) H2
c) Adjuvants
d) Haplotype
8) All the individual of the same species has the same allele of MHC genes.
a) True
b) False
9) Which of the following polypeptide is important for the expression of MHC I on the cell
membrane?
a) Interferons
b) β2-microglobin
c) Lymphokines
d) Interleukins
Answer: b
Explanation: β2-microglobin is encoded by chromosome 15, it is always attached to
α3 subunit of MHC I molecules through non-covalent interactions. It does not have a tail.
10) Which of these are non-professional antigen presenting cells?
a) Macrophages
b) Dendritic cells
c) Fibroblast
d) B lymphocytes
Answer: c
Explanation: Antigen presenting cells (APC) is of two types i.e. professional and non-
professional antigen presenting cells. Professional antigen presenting cells are B-
lymphocytes, dendritic cells, and macrophages while non-professional APCs are fibroblast,
epithelial cells, glial cells etc.
11) Name the cell which receives antigen presented by MHC molecule.
a) Nk cells
b) B-cells
c) T-cells
d) Macrophages
12) Name the part of processed antigen that binds to the MHC molecule and recognized by
T-cells?
a) Immunoglobulin
b) Agretope
c) Epitope
d) Chaperone
Answer: b
Explanation: Agretope is the part of processed antigen that is attached to MHC molecule
and exposed to T-cell.
13) Which of the following statement is INCORRECT about superantigens?
a) Viral or bacterial proteins
b) Endogenous by nature
c) Unique binding ability
d) Activate a large number of T-cells
Answer: b
Explanation: Superantigens are viral or bacterial proteins which have the unique binding
ability of T-cell receptor and MHC II molecules, i.e. it binds simultaneously to both and
activate large numbers of T-cells. It can be both either endogenous or exogenous in nature.
