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Protein Structure Past Questions

Human Factor VIII is a glycoprotein essential for blood clotting, consisting of 2332 amino acids in a complex structure. It is produced artificially using genetic engineering techniques to treat hemophilia by inserting the Factor VIII gene into hamster cells. The resulting Factor VIII is then harvested and purified for medical use.

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7 views2 pages

Protein Structure Past Questions

Human Factor VIII is a glycoprotein essential for blood clotting, consisting of 2332 amino acids in a complex structure. It is produced artificially using genetic engineering techniques to treat hemophilia by inserting the Factor VIII gene into hamster cells. The resulting Factor VIII is then harvested and purified for medical use.

Uploaded by

rockgame.b4l
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© © All Rights Reserved
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2. Read the following passage and then answer the questions that follow.

Human Factor VIII is a glycoprotein found in blood plasma. It is involved in


blood clotting.

This glycoprotein contains 2332 amino acids linked into a single chain.
This chain is folded and coiled into a secondary structure and then further
folded. The chain
5 forms six individual regions, each with its own function.

An artificial source of Factor VIII, created using genetic engineering, is now


used to treat patients with haemophilia, a medical condition in which the
blood clots more slowly than normal. The Factor VIII gene is first removed
from the genome of human cells. It is then inserted into the genome of
hamster cells.

10 Cancer cells or cells taken from an ovary are usually used to produce
Factor VIII as these grow very well in industrial tanks. The Factor VIII that
is produced is then removed from the tanks and purified before use in
treating patients.

(a) State what is meant by the term glycoprotein (line 1).

.......................................................................................................................
..

...................................................................................................................[1]

(b) The secondary structure of a protein is identified by its shape.

(i) Name a shape formed by coiling of the primary structure.

...........................................................................................................[1]

(ii) Name a shape formed by folding of the primary structure.

..........................................................................................................[1]

(c) State the name given to the level of structure formed by further folding of
the secondary structure (line 4).

.......................................................................................................................
..
[1]
[Total 4 marks]

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