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B.tech. BioTech

The document outlines the course objectives and structure for a Bioprocess Engineering class, focusing on bioreactor engineering and bioengineering skills for biochemical production. It includes five units covering bioreactor configurations, scale-up processes, enzyme systems, modeling and simulation of bioprocesses, and recombinant cell cultivation. Upon completion, students will be equipped to describe bioreactor operations, apply scale-up knowledge, and utilize modeling approaches for bioprocess estimations.

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SEDHU PATHI S
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11 views1 page

B.tech. BioTech

The document outlines the course objectives and structure for a Bioprocess Engineering class, focusing on bioreactor engineering and bioengineering skills for biochemical production. It includes five units covering bioreactor configurations, scale-up processes, enzyme systems, modeling and simulation of bioprocesses, and recombinant cell cultivation. Upon completion, students will be equipped to describe bioreactor operations, apply scale-up knowledge, and utilize modeling approaches for bioprocess estimations.

Uploaded by

SEDHU PATHI S
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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BT3651 BIOPROCESS ENGINEERING LTPC

3003
COURSE OBJECTIVES:
The student should be made to,
 To provide the students with the basics of bioreactor engineering.
 To develop bioengineering skills for the production of biochemical product using integrated
biochemical processes.

UNIT I CONFIGURATION OF BIOREACTORS 9


Ideal reactors and its characteristics Fed batch cultivation, Cell recycle cultivation, Cell recycle
cultivation in waste water treatment, two stage cultivation Packed bed reactor, airlift reactor,
introduction to fluidized bed reactor bubble column reactors

UNIT II BIOREACTOR SCALE – UP 9


Regime analysis of bioreactor processes, oxygen mass transfer in bioreactors – microbial oxygen
demands; methods for the determination of mass transfer coefficients; mass transfer correlations.
Scale up criteria for bioreactors based on oxygen transfer, power consumption and impeller tip
speed.

UNIT III BIOREACTOR CONSIDERATION IN ENZYME SYSTEMS 9


Analysis of film and pore diffusion effects on kinetics of immobilized enzyme reactions; formulation
of dimensionless groups and calculation of effectiveness factors. Design of immobilized enzyme
reactors – packed bed, fluidized bed and membrane reactors

UNIT IV MODELLING AND SIMULATION OF BIOPROCESSES 9


Study of structured models for analysis of various bioprocess – compartmental models, models of
cellular energetics and metabolism, single cell models, plasmid replication and plasmid stability
model. Dynamic simulation of batch, fed batch, steady and transient culture metabolism.

UNIT V RECOMBINANT CELL CULTIVATION 9


Different host vector system for recombinant cell cultivation strategies and advantages. E.coli,
yeast Pichia pastoris/ Saccharomyces cereviseae, Animal cell cultivation, plant cell cultivation,
Insect cell cultivation. High cell density cultivation, process strategies, reactor considerations in the
above system
TOTAL: 45 PERIODS
OUTCOMES:
Upon completion of this course the student will be able to
 Describe various bioreactor configurations and operation modes.
 Apply the knowledge of bioreactor scale up on the basis of rule of thumbs.
 Define kinetic parameters and apply the bioreactor considerations for immobilized
enzymes systems.
 Utilize modelling approaches and simulation concepts for bioprocess estimations.
 Apply bioreactor considerations for the development of recombinant products.
 Explore the engineering concepts of bioreactors.

TEXT BOOKS:
1. Michael L. Shuler, Fikret Kargi, Matthew De Lisa,.Bioprocess Engineering,
3rdEdition,Prentice Hal, 2017
2. Pauline Doran, Bioprocess Engineering Calculation, 2nd Edition, Blackwell Scientific
Publications,2012.
3. Sarfaraz K. Niazi, Justin L. Brown , Fundamentals of Modern Bioprocessing, Taylor &
Francis,2017

98

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