The document discusses the origins and evolution of the universe and life on Earth, starting from the Big Bang theory to the emergence of life forms. It outlines various theories regarding the origin of life, such as panspermia, spontaneous generation, and chemical evolution, and presents evidence for evolution through paleontology, embryology, comparative anatomy, and molecular biology. Additionally, it explains concepts like adaptive radiation and natural selection, emphasizing that evolution is a stochastic process influenced by environmental conditions.
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Evolution Fast Revision
The document discusses the origins and evolution of the universe and life on Earth, starting from the Big Bang theory to the emergence of life forms. It outlines various theories regarding the origin of life, such as panspermia, spontaneous generation, and chemical evolution, and presents evidence for evolution through paleontology, embryology, comparative anatomy, and molecular biology. Additionally, it explains concepts like adaptive radiation and natural selection, emphasizing that evolution is a stochastic process influenced by environmental conditions.
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ofl
igi of univers
ie universe is very old — almost 20 billion years
4, Huge clusters of galaxies comprise the
Galaxies contain stars and clouds of gas and dust.
Considering the size of universe, earth is indeed
a speck
The Big Bang theory attempts to explain to us
the origin of universe. It talks of a singular huge
explosion unimaginable in physical terms.
‘The universe expanded and hence, the tempera-
ture came down,
Hydrogen and Helium formed sometime later.
ation and
+ The gases condensed under grav
formed the galaxies of the present day universe.
In the solar system of the milky way galaxy,
earth was supposed to have been formed about
45 billion years back.
There was no atmosphere on early earth, Water
vapour, methane, CO, and ammonia released
from molten mass covered the surface.
‘The UV rays from the sun brokeup water into
fiydrogen and Oxygen and the lighter H,
escaped.
Oxygen combined with ammonia and methane
tp form water, CO, and others, The ozone layer
was formed.
i Asit cooled, the water vapour fell as rain, to fill
all the depressions and form oceans.
+ Life appeared 500 million years after the formation
of earth, ie., almost 4 billion years back.
Theory of panspermia:
Did life come from outerspace? Some scientists
believe that it came from outside. Early Greek
thinkers thought units of life called spores were
transferred to different planets including earth.
‘Panspermia’ is still a favourite idea for some
‘stonomers,
Theory of spontaneous generation:
*
For a long time it was also believed that life came
out of decaying and rotting matter like straw,
mud, etc. This was the theory of spontaneous
generation
Louis Pasteur by careful experimentation
demonstrated that life comes only from pre-
existing life
He showed that in pre-sterilised flasks, life did
not come from killed yeast while in another flask
open to air, new living organisms arose from
‘killed yeast’
Spontaneous generation theory was dismissed
‘once and for all. However, this did not answer
how the first life form came on earth.
Theory of chemical evolution:
Oparin of Russia and Haldane of England
proposed that the first form of life could have
come from pre-existing non-living organic
molecules (e.g. RNA, protein, etc.) and that
formation of life was preceded by chemical
evolution, i.e., formation of diverse organic
molecules from inorganic constituents.
The conditions on earth were —
temperature, volcanic storms, reducing
atmosphere containing CH,, NH, etc.
In 1953, S.L. Miller, an American scientist
lar conditions in a laboratory scale
igh
created s
(Figure).
He created electric discharge in a closed flask
containing CHy Hy NH, and water vapour at
800°C, He observed forthation of amino acids.
In similar experiments others observed, forma-
tion of sugars, nitrogen bases, pigment and fats.
Scanned with CamScani* Analysis of meteorite content also re’
similar compounds indicating that similar
processes are 0
led
turting elsewhere in space.
%* With this limited evidence, the first part of the
speculated story, i.e. chemical evolution was
more or less accepted,
We have no idea about how the first self-
replicating metabolic capsule of life arose,
% The first non
ellular forms of life could have
originated 3 billion years back. They would
have been giant molecules (RNA, Protein,
Polysaccharides, etc.). These capsules
reproduced their molecuies perhaps.
* The first cellular form of life did not possibly
originate till about 2000 million years ago. These
were probably
* All
gle-cells.
forms were in water environment only.
version of a biogenesis, i.e., the first form
of life arose slowly through evolutionary forces
from non-living molecules is accepted by
majority
EVOLUTION OF LIFE FORMS - A THEORY
* Conventional religious literature tells us about
the theory of special creation.
* This theory has three connotations (suggested
or implied outlines).
1. all living organisms (species or types) that
we see today were created as such.
2. the diversity was always the same since
creation and will be the same in future also,
3. earth is about 4000 years old.
% All these ideas were strongly challenged during
the nineteenth century.
+ Based on observations made during a sea voyage
in a sail ship called H.M.S. Beagle round the
world, Charles Darwin concluded that existing
living forms share similarities to varying degrees
not only among themselves but also with life
forms that existed millions of years ago. Many
such life forms do not exist any more,
There had been extinctions of different life forms
in they ears gone by just as new forms of life
arose at different periods of history of earth,
de There has been gradual evolution of life form
4 Any population has built in variation in charg
teristics. Those characteristics Which enable som,
to survive better in natural conditions (climate,
food, physical factors, etc.) would outbreeg
(reproduce more quickly) others that are ess.
endowed (less equipped) (0 survive under sych
natural conditions.
& Another word used is fitness of the individya)
or population. The fitness, according to Darwin,
refers ultimately and only to reproductive
fitness, Hence, those who are better fit in an
environment, leave more progeny than others,
These, therefore, will survive more and hence _
are selected by nature. He called it naturaj
;
selection and implied it as a mechanism of
evolution.
‘Also remember that Alfred Wallace, a naturalist
who worked in Malay Archipelago had also
come to similar conclusions around the same
time.
+ In due course of time, apparently new types of,
organisms are recognisable.
* All the existing life forms share similarities and
share common ancestors. However, these
ancestors were present at different periods in the
history of earth (epochs, periods and eras).
* The geological history of earth closely
correlates with the biological history of earth.
WHAT ARE THE EVIDENCES FOR
EVOLUTION?
Evidence that evolution of life forms has indeed taken
place on earth has come from many quarters.
Paleontological evidence:
% Fossils are remains of hard parts of life-forms
found in rocks.
* Rocks form sediments and a cross-section
earth’s crust indicates the arrangement
sediments one over the other during the lo
history of earth. 5
* Different aged rock sediments contain fos
different life-forms who probably died ¢
the formation of the particular sediment.
Scanned with CamScani—
, study of fossils in different sedimentary layers
indicates the geological period in which they
existed. The study showed that life-forms varied
over time and certain life forms are restricted to
certain geological timespans. Hence, new forms
of life have arisen different times in the history
of earth.
iat is radioactive-dating? State the principle
yetind the procedure,
, It is a dating method of determining the age of
earth materials or objects of organic origin based
on measurement of either short lived radioactive
elements or the amount of a long-lived
radioactive element plus its decay product.
+ Principle - Each radioactive element decays at
its own nearly constant rate. Once this rate is
known, geologists can estimate the length of time
over which decay has been occurring by
measuring the amount of radioactive parent
clement, the amount of stable daughter elements
and the amount of radioactive substances left,
thus giving the age of the different things like
rocks.
Embryological evidences:
+ Embryological support for evolution was also
proposed by Ernst Haeckel based upon the
observation of certain features during embryonic
stage common to all vertebrates that are absent
in adult.
+ For example, the embryos of all vertebrates
including human develop a row of vestigial gill
slit just behind the head but it is a functional
organ only in fish and not found in any other
adult vertebrates.
* However, this proposal was disapproved on
careful study performed by Karl Ernst von
Baer. He noted that embryos never pass through
the adult stages of other animals.
[Evidences from comparative anatomy and
morphology:
+ Comparative anatomy and morphology shows
similarities and differences among organisms of
+t For example whales, bats, Cheetah and human
(all mammals) share similarities in the pattern of
bones of forelimbs. Though these forelimbs
perform different functions in these animals,
they have similar anatomical structure ~ all of
them have humerus, radius, ulna, carpals,
metacarpals and phalanges in their forelimbs.
+ Hence, in these animals, the same structure
developed along different directions due to
adaptations to different needs. This is Divergent
Evolution and these structures are homologous.
% Homology indicates common ancestry. Other
examples are vertebrate hearts or brains.
% In plants also, the thorn and tendrils of
Bougainvillea and Cucurbita represent
homology.
% Homology is based on divergent evolution
whereas analogy refers to a situation exactly
opposite.
% Wings of butterfly and of birds look alike. They
are not anatomically similar structures though
they perform similar functions.
% Hence, analogous structures are a result of
Convergent Evolution different structures
evolving for the same function and hence having
similarity.
% Other examples of analogy are the eye of the
octopus and of mammals or the flippers of.
Penguins and Dolphins.
* One can say that it is the similar habitat that has
resulted in selection of similar adaptive features
in different groups of organisms but toward the
same function:
+ Sweet potato (root modification) and potato (stem
modification) is another example for analogy.
Biochemical (molecular) evidences:
* In the same line of argument, similarities in
Proteins and genes performing a given function
among diverse organisms give clues to common
ancestry.
+ These biochemical simil
today and those that existed years ago. ati ae a om tietsame
i i jctural similarities a
+ Such similarities can be interpreted to understand diverse organisms S among
whether common ancestors were shared or not
=
canned With VamscaniObservations supporting evolution by selection:
* Man has bred selected plants and animals for
agriculture, horticulture, sport or security. Man
has domesticated many wild animals and crops.
This intensive breeding programme has created
breeds that differ from other breeds (¢.g., dogs)
but still are of the same group.
* It is argued that if within hundreds of years, man
could create new breeds, could not nature have
done the same over million
Industrial melanism:
of years?
Another inter
ting observation supporting
evolution by natural selection comes from
England.
* In a collection of moths made in 1850s, i.e.,
before industrialisation set in, it was observed
that there were more white-winged moths on
trees than dark-winged or melanised moths
* However, in the collection carried out from the
same area, but after industrialisation, ie. in 1920,
there were more dark-winged moths in the same
area, i.e., the proportion was reversed.
* The explanation put forth for this observation
was that ‘predators will spot a moth against a
contrasting background”.
* During post industrialisation period, the tree
trunks became dark due to industrial smoke and
soots.
%* Under this condition the white-winged moth did
not survive due to predators, dark-winged or
melanised moth survived.
% Before industrialisation set in, thick growth of
almost white-coloured lichen covered the trees
- in that background the white winged moth
survived but the dark-coloured moth were picked
out by predators.
% Lichens can be used as industrial pollution
indicators. They will not grow in areas that are
polluted, Hence, moths that were able to camou-
flage themselves, i.e., hide in the background,
survived.
% This understanding is supported by the fact that
in areas where industrialisation did not occur
eg, in rural areas, the count of melanic moths
was low.
This showed that in a mixed population
sth,
that can better-adapt, Survive and jngys
cP
ion size, se ig
population size.
‘% Remember that no variant is completely
out
J Similarly, excess use of herbicides, pesiig,
_ has only resulted in selection of resigy
ties in a much lesser time scale.
tan
2 This is also true for microbes against which 4.
employ antibiotics or drugs against eukaryoi.
organisms/cell
+ Hence, resistant organisms/cells are appearing
in a time scale of months or years and yo,
centuries. These are examples of evolution by
anthropogenic action.
% This also tells us that evolution is not a directed
process in the sense of determinism, It is 4
stochastic process based on chance events in
nature and chance mutation in the organisms,
In simple language:
% Evolution is not planned. There is no step by
step process that it followed to reach from one
celled organisms to more developed animals
like humans through fishes and amphibians,
%* There was a probability that the world could be
something completely different than what itis
right now if the conditions were even a slightly
different.
* Evolution is random. If the environmental
conditions favour heat resistant organisms, the
heat resistant organisms flourish and increase
in number making maximum proportion of the
population.
* Nobody can predict what change might occir
in nature or what mutation takes place in am
organism and hence nobody can predict what
direction evolution will move forward in.
WHAT IS ADAPTIVE RADIATION?
% The process of evolution of different species i?
a given geographical area starting on
Point and literally radiating to other area
geography (habitats) is called adapti'®
radiation.
Scanned with CamScanisample No. 1:
puring his journey Darwin went to Galapagos
" Jslands. There he observed an amazing diversity
of creatures.
of particular interest, small black birds later
* called Darwin’s Finches amazed him, He
realised that there were many varieties of finches
in the same island,
+ All the varieties, he speculated, evolved on the
island itself. From the original seed-eating
features, many other forms with altered beaks
arose, enabling them to become insectivorous
and vegetarian finches,
+ Darwin’s finches represent one of the best
examples of this adaptive radiation.
0, Can Human Evolution be called as Adaptive
Radiation?
No, human evolution cannot be called an
adaptive radiation,
This is because adaptive radiation is an
evolutionary process that produces multiple new
species from a single, rapidly diversifying
lineage.
Human evolution is a slow, lengthy and
continuing process which was originated from
ape like ancestors evolved over a period of
approximately five to six million years ago.
Human evolution can be categorized into each
species as each milestone. Human evolution
represents an example of anagenesis.
(Amagenesis is the gradual evolution of a species
that continues to exist as an interbreeding
population)
Example No. 2:
Another example is Australian marsupials. A
dumber of marsupials, eachdifferent from the other
(Figure) evolved from an ancestral stock, but all
Within the Australian island continent,
‘Tasmanian wolt
nwa
te
Morsupiat EGR
Lv. a cat
7 BRN
‘ =
FE andes
Koala AUSTRALIA 4 anteater
¥
Marsupial
Bandicoot rat
Rais
‘Wombat ‘Kangaroo
Fig. Adaptive radiation of marsupials of
Australia
When more than one adaptive radiation appeared
to have occurred in an isolated geographical
area (Representing different habitats), one can
call this convergent evolution.
Placental mammals in Australia also exhibit
adaptive radiation in evolving into varieties of
such placental mammals each ofwhich appears
to be ‘similar’ to a corresponding marsupial (e.g.,
Placental wolf and Tasmanianwolf-marsupial).
Scanned with CamScaniNiche
tralian marsupials _
| oe
| | ‘ >
Sorewacd | {ep
| Marsupial
zt
Anteater
AF?
Numbat (anteater) |
hoe | ~~ RR % Agen
Mouse
Anteater
Marsupial mouse
ct
Lemur
Glider —
Flying squirrel phalanger|
4 |
Cat ie |
‘Ocelot | Tasmanian tiger cat
‘Wolf
/ e Tasmanian wolf
Difference between adaptive radiation and
convergent evolution?
%* Adaptive radiation refers to an evolutionary
process in which different species evolve from
‘a common ancestor, on inhabiting new areas as
they successfully adapt to their environment;
while convergent evolution is an evolutionary
process in which different structures of different
species are evolved for the same function.
% Hence during adaptive radiation, the changes are
determined by the environment. The organism
evolves to survive in a particular environment.
% Therefore, if two different adaptive radiation
occurs in an area, then it is most likely that both
the evolved species will have similar adaptations
to survive in that particular area.
% Hence, they will develop similar structures to
perform similar functions.
BIOLOGICAL EVOLUTION
*
Evolution by natural selection, in a true,
would have started when cellular forms a
with differences in metabolic capa”
originated on earth ity,
‘The essence of Darwinian theory about eyo),
is natural selection. The rate of appearance.
new forms is linked t0 the life evcle or they
span. _
Microbes that divide fast have the abitiy
multiply and become millions of individu,
within hours, A colony of bacteria (say 4,
growing on a given medium has built-in vaitng
in terms of ability to utilise a feed componen,
‘A change in the medium composition woutg
bring out only that part of the population (sy
B) that can survive under the new conditions,
In due course of time this variant population
‘outgrows the others and appears as new species
‘This would happen within days. For the same
thing to happen in a fish or fowl would take
millions of years as life spans of these animals
are in years.
Here we say that fitness of B is better than that
of A under the new conditions.
Nature selects for fitness.
‘One must remember that the so-called fitness is
based on characteristics which are inherited.
Hence, there must be a genetic basis for getting
selected and to evolve.
Another way of saying the same thing is that
some organisms are better adapted to survive it
an otherwise hostile environment.
Adaptive ability is inherited. It has a genetic
basis.
Fitness is the end result of the ability to adapt
and get selected by nature.
Branching descent and natural selection are the
two key concepts of Darwinian theory
evolution.
Even before Darwin, a French naturalist
Lamarek had said that evolution of life fo™
had occurred but driven by use and dists?
organs.He gave the examples of Giraffes who in an
* tempt to forage leaves on tall trees had to adapt
by elongation of their necks.
‘As they passed on this acquired character of
elongated neck to succeeding generations,
Giraffes, slowly, over the years, came to acquire
Jong necks. Nobody believes this conjecture any
more.
cd stelcing nt
aap si nea becomes
eckiovesceoves tnd progressively loose
ofgiat Neher upaties... vetoing
‘Grane
Salient Features of Darwin’s Theory of Evolution:
PE als =) [ean
preston of| =| beds cs ce
Popuiaton || pase’ | [oestence| > [Ye
Fermaton | __[Iertance
nat mettane Natal
Ginow” | | tesa | co | sua
Salient Features of Lamarck’s Theory of Evolution:
Speciaton}
Q. Is evolution a process or the result of a process?
‘The world we see, in animate and animate, is
only the success stories of evolution. When we
describe the story of this world we describe
evolution as a process.
* On the other hand when we describe the story of
life on earth, we treat evolution as a consequence
of a process called natural selection.
* We are still not very clear whether to regard
evolution and natural selection as processes or
end result of unknown processes.
%* It is possible that the work of Thomas Malthus
on populations influenced Darwin. Natural
selection is based on certain observations which
are factual
* For example, natural resources are limited,
populations are stable in size except for seasonal
fluctuation, members of a population vary in
characteristics (in fact no two individuals are
alike) even though they look superficially similar,
most of variations are inherited etc.
%* The fact that theoretically population size will
grow exponentially if everybody reproduced
maximally (this fact can be seen in a growing
bacterial population) and the fact that population
sizes in reality are limited, means that there had
been competition for resources.
% Only some survived and grew at the cost of
others that could not flourish. The novelty and
brilliant.
Insight of Darwin was this: he asserted that
Variations, which are heritable and which make
Tesource utilisation better for few (adapted to
habitat better) will enable only those to
reproduce and leave more progeny.
* Hence for a period of time,
5 over many
generations,
survivors will leave more pro;
geny
and there would be a change in population
characteristic and hence new fi
forms aj
pS Ppear to
MECHANISM OF EVOLUTION
* What is the origin of this
= variation an
does speciation occur? how
Scanned with CamScani(biggest weakness of Darwinism)
% In the first decade of twentieth century, Hugo
deVries based on his work on Qenothera
lamarckiana (evening, primrose) brought forth
the idea of mutations ~ large difference arising
suddenly in a population.
He believed that it is mutation which causes
evolution and not the minor variations (heritable)
that Darwin talked about
Mutations are random and directionless while
Darwinian variations are small and directional,
** Evolution for Darwin was gradual while deVries
believed mutation caused speciation and hence
called it saltation (single step large mutation).
HARDY-WEINBERG PRINCIPLE
* In a given population one can find out the
‘quency of occurrence of alleles of a gene or a
locus. This frequency is supposed to remain fixed
and even remain the same through generations,
* Hardy-Weinberg principle stated it using
algebraic equations,
%* This principle says that allele frequencies in a
population are stable and is constant from
generation to generation,
% The gene pool (total genes and their alleles in a
population) remains a constant, This is called
genetic equilibrium. Sum total of all the allelic
frequencies is 1
%* Individual frequencies, for example, can be
named p, q, etc. In a diploid, p and q represent
the frequency of allele A and allele a,
%* The frequency of AA individuals in a population
is simply p?.
% This is simply stated in another ways, ie., the
probability that an allele A with a frequency of p
appear on both the chromosomes of a diploid
individual is simply the product of the
probabilities, i.e., p*.
* Similarly of aa is q?, of Aa 2pq. Hence, p? + 2pq
adie
% This is a binomial expansion of (p+q)?.
% When frequency measured, differ,
expected values, the difference (qj,
indicates the extent of evolutionary ch,
® ftom
TeCtign,
lange,
% Disturbance in genetic equilibrium, or ja,4
Weinberg equilibrium, i.e., change”
frequency of alleles in a population would tye,
be interpreted as resulting in evolution,
Factors that affect Hardy-Weinberg equilipriyyy,
%* Five factors are known to affect Hardy.
Weinberg equilibrium. These are gene
or gene flow, genetic drift, mutation, genetic
recombination and natural selection,
% When migration of a section ofpopulation to
another place and population occurs, gene
frequencies change in the original as well as in
the new population.
+ New genes/alleles are added to the new
population and these are lost from the old
population. There would be a gene flow if this
gene migration, happens multiple times. If the
same change occurs by chance, it is called
genetic drift.
% Sometimes the change in allele frequency is so
different in the new sample of population that
they become a different species. The original
drifted population becomes founders and the
effect is called founder effect.
* Microbial experiments show that pre-existing
advantageous mutations when selected will
result in observation of new phenotypes.
* Over few generations, this would result in
Speciation.
+ Natural selection is a process in which heritable
variations enabling better survival are enabled
to reproduce and leave greater number of
progeny. A critical analysismakes us believe that
variation due to mutation or variation due to
recombination during gametogenesis, or due t0
gene flow or genetic drift results in changed
frequency of genes and alleles in future
generation.
% Coupled to enhance reproductive success,
natural selection makes it 100k like different
scanned with Camscalpopulation
. of natural selection:
Natural selection can lead to stabilisation (in
* hich more individuals acquire mean character
fnlue), directional change (more individuals
acquire value other than the mean character
olue) or disruption (more individuals acquire
peripheral character value at both ends of the
distribution curve).
) Stabilizing selection
Population
after natural
“Ina hypothetical population, gray and Himalayan
| (gray and white) rabbits are better able to blend
with a rocky environment than white rabbits,
resulting in diversifying selection
g
(p) Directional selection
Population after
natural selection.
Original
population
Robins typically lay four eggs, an example of
stabilizing selection. Larger clutches may result in
malnourished chicks, while smaller clutches may
result in no viable offspring,
(c) Diversifying selection
Population after
natural selection
Original
population
Light-colored peoppered months are better
comouflaged against a pristine environment;
likewise, dark-colored peppered months are better
comoflaged against a sooty environment. Thus, as
the in nineteenth-century England, the color of the
moth population shifted from light to dark, an
example of directional selection.
SOLVED EXAMPLES OF HARDY WEINBERG
EQUATION:
Example 1. The frequency of two alleles in a gene
pool is 0.19 (A) and 0.81 (a). Assume that the
population is in Hardy-Weinberg equilibrium.
(a) Calculate the percentage of heterozygous
individuals in the population.
Sol. According to the Hardy-Weinberg Equilibrium
equation, heterozygotes are represented by the
2pq term, Therefore, the number of heterozygous
individuals (Aa) is equal to 2pq which equals
2 x 0.19 x 0.81 = 0.31 or 31%.
(b) Calculate the percentage of homozygous
recessives in the population.
Sol. The homozygous recessive individuals (aa) are
represented by the q? term in the H-W equilibrium
equation which equals 0.81 x 0.81 = 0.66 or 66%.
Example 2. An allele W, for white wool, is dominant
over allele w, for black wool. In a sample of 900
sheep, 891 are white and 9 are black. Calculate the
Scanned with CamScaniallelic frequencies within this population, assuming
that the population is in H-W equilibrium
Sol. The allelic frequency of w is represented by the
q term and the allelic frequency W is represented by
the p term, To calculate the value of q, realize that
qq or q? represents the homozygous recessive
individuals or the black sheep in this case. Sin
there are 9 black sheep, the frequency of black sheep.
#individuals __9 _ 9.9}
total individuals. 900”
thus ww = q?= 0.01 - a=Ve =V00i=0.1
Additionally, p + q = 1, thus p= 1-4
(or) p= 1-0.1 (or) 0.9
> p=W=0.9 and q=w=0.1
Example 3. In a population that is in Hardy-
Weinberg equilibrium, the frequency of the recessive
homozygote genotype of a certain trait is 0.09
Calculate the percentage of individuals homozygous
for the dominant allele.
Sol.We know that the frequency of the recessive
homozygote genotype is q? and equal to 0.09.
30 and we also know that
Thus, p=1-q « p=1-030=0.70
<. The homozygote dominants are represented
by p? = (0.70) = 0.49 or 49%
Example 4, In a population that is in Hardy-
Weinberg equilibrium, 38% of the individuals are
recessive homozygotes for a certain trait. In a
0, calculate the percentage of
ant individuals and hetero-
population of 14,50
homozygous domin;
zygous individuals.
Sol.Always start with the homozygous recessive
percentage if given, which is equal to 4°.
naq= Ya? = V038 -. a= 0.616
Solving for p is now straight forward : p+4
thus p=} -q=1-9=1~0.616 = 0.384
‘The homozygous dominant individ
represented by p? = 0.3847 = 0.147
14,500 x 0.0147 = 2,132 homozygous
uals are
dominant individuals
The heterozygotes are represented by the 2p,
= 2x 0616 x 0.384 =0473
859
term and 2pq
14,500 x 0.473
Double check : 0.38 x 14,500 = 5.510
4,501
(due to some rounding)
5,510 + 2,132 + 6,859 =
Example 5. In humans, the Rh factor genetic
information is inherited from our parents, but itis
inherited independently of the ABO blood type
alleles, In humans, Rh* individuals have the Rh
antigen on their red blood cells, while Rh
individuals do not. There are two different alleles
for the Rh factor known as Rh* and rh. Assume that
a dominant gene Rh produces the Rh* phenotype,
‘and that the recessive th allele produces the Rl
phenotype.
In a population that is in Hardy-Weinberg
equilibrium, if 160 out of 200 individuals are
Rht, calculate the frequencies of both alleles.
Sol. Always start with the homozygous recessive
percentage if given, which is equal 10 4°
If 160 and 200 individuals are Rh*, then it stands
to reason that 40 are Rhr.
Thus, the frequency of q*, the Rhr genotype is
40
——=0.20
200
=, q=¥0.20 (01) q= 0.45 and p+4=1
so, p=1-q=1-045 = 0.55
, Rh* allele frequency = 0.55 and th allele
frequency = 0.45
(A BRIEF ACCOUNT OF EVOLUTION
About 2000 million years ago (mya) the first
cellular forms of life appeared on earth.
se Some of these cells had the ability to release O,,
‘The reaction could have been similar to the light
reaction in photosynthesis where water is split
with the help of solar energy captured and
channelised by appropriate light harvesting
pigments.
# Slowly single-celled organisms became multi-
cellular life forms.
Scanned with CamScanipy the time of 500 mya, invertebrates were
* formed and active
Jawless fish probably evolyed around 350
mya.
sea weeds and few plants existed probably
around 320 mya,
We are told that the first organisms that invaded
land were plants. They were wide spread on land
when animals invaded land.
Fish with stout and strong fins could move on
land and go back to water, This was about
350mya.
+ In1938, a fish caught in South Africa happened
to be a Coelacanth which was thought to be
extinct. These animals called lobe fins evolved
into the first amphibians that lived on both land
and water. There are no specimens of these left
with us, However, these were ancestors of modern
day frogsand salamanders.
+ The amphibians evolved into reptiles. They lay
thick shelled eggs which do not dry up in sun
unlike those of amphibians. Again we only see
their modern day descendants, the turtles,
tortoises and crocodiles.
+ In the next 200 million years or so, reptiles of
different shapes and sizes dominated on earth
+ Giant ferns (pteridophytes) were present but they
all fell to form coal deposits slowly.
+ Some of these land reptiles went back into water
to evolve into fish like reptiles probably 200mya
(e.g. Ichthyosaurs).
+ The land reptiles were, of course, the dinosaurs.
The biggest of them, i.e., Tyrannosaurus rex
was about 20 feet in height and had huge fear
some dagger like teeth.
‘About 65 mya, the dinosaurs suddenly
disappeared from the earth. We do not know the
true reason. Some say climatic changes Killed
them, Some say most of them evolved into birds.
The truth may live in between. Small sized
reptiles of that erastill exist today.
x
The first mammals were like shrews. Their fossils
are small sized.
% Mammals were viviparous and protected their
unborn young inside the mother’s body
+ Mammals were more intelligent in sensing and
avoiding danger at least. When reptiles came
down mammals took over this earth.
There were in South America mammals
resembling horse, hippopotamus, bear, rabbit
ete
%* Due to continental drift, when South America
joined North America, these animals were
overridden by North American carnivorous
fauna
# Due to the same continental drift pouched
mammals of Australia survived because of lack
of competition from any other mammal.
* Lest we forget, some mammals live wholly in
water. Whales, dolphins, seals and sea cows are
some examples. Evolution of horse, elephant,
dog.etc., are special stories of evolution.
Different types of dinosaurs:
rie,
Tyranvosourous —Stegosauus
he
Treeratns
Biggest carnivorous dinosaur
Biggest herbivorous dinosaur
* Tyrannosaurus
* Brachiosaurus
* Ichthyosaurus
* Pteranodon
Aquatic dinosaur
Flying dinosaur
Scanned witn LamscaniEVOLUTION OF REPTILES, BIRDS & MAMMALS:
| Turtle Lizards
| Coenozoie Era
(Dur.65M yrs)
Mesozoic Era
(Dur.180M yrs) =
Sauropsids
| Palaeozoic Era
|(Dur.300M yrs)
| Stem Reptiles]
Some primitive reptiles :
Eye Seren
A
ORIGIN AND EVOLUTION OF MAN
% The most successful story of evolution is the
evolution of man with language skills and self-
consciousness.
%* About 15 mya, primates called Dryopithecus
and Ramapithecus were existing. They were
hairy and walked like gorillas and chimpanzees,
Ramapithecus was more man-like while
Dryopithecus was more ape-like.
% Few fossils of man-like bones have been
discovered in Ethiopia and Tanzania. These
revealed hominid features leading tothe belief
that about 3-4 mya, man-like primates walked
in Eastern Africa. They were probably not taller
than 4 feet but walked up right.
Snakes
a Synapsids
*
Tuatara
Crocodile Birds M
ammaly)
Dinosaurs
odont
‘Two mya, Australopithecines probably lived jp
East African grasslands, Evidence shows thy
hunted with stone weapons but essentially ate
fruit.
Some of the bones among the bones discovered
were different. This creature was called the firs
human-like being the hominid and was called
Homo habilis.The brain capacities were between
650-800cc. They probably did not eatmeat
Fossils discovered in Java in 1891 revealed the
next stage, i.e., Homo erectus about 1.5 mya
Homo erectus had a large brain around 900cc.
Homo erectus probably ate meat.
‘The Neanderthal man with a brain size of 1400cc
lived in near East and Central Asia between
1,00,000-40,000 years back. They used hides
to protect their body and buried their dead.
Homo sapiens arose in Africa and moved across
continents and developed into distinct races.
During ice age between 75,000-10,000 years
agomodern Homo sapiens arose.
Pre-historic cave art developed about 18,000
years ago.
One such cave paintings by Pre-historic humans
canbe seen at Bhimbetka rock shelter in Raisen
district of Madhya Pradesh.
Agriculture came around 10,000 years back and
human settlements started.
Scanned with CamScani