Infectious diseases articles from across Nature Portfolio

Metabolic pathways are important for all biological processes, including host defence against pathogens. We show that activation of innate immune signalling is primed by oxaloacetate sensing through the cytosolic malate dehydrogenase MDH1, ensuring optimal production of type I interferons and host immune homeostasis in response to influenza virus infection.

Human antibodies DENV-290 and DENV-115 are ultrapotent against dengue virus 3 strains with differing particle morphologies. CryoEM shows both bind across two protomers at the center of the envelope protein dimer, defining a new class of epitope.

Computational models can help to explain the dynamics of cellular infection with pathogens. Here the authors use computational models to assess the single cell infection parameters of human macrophage infection with Legionella pneumophila and the effects on immunometabolism at a single cell and population level.

Metabolic pathways are important for all biological processes, including host defence against pathogens. We show that activation of innate immune signalling is primed by oxaloacetate sensing through the cytosolic malate dehydrogenase MDH1, ensuring optimal production of type I interferons and host immune homeostasis in response to influenza virus infection.

Offering free-of-charge in-hospital influenza vaccination improves survival and reduces changes of readmission in patients with advanced heart failure, according to a large cluster-randomized trial across hospitals in China.

A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current science landscape.