Metabolic pathways articles from across Nature Portfolio

Greda et al. show that sortilin and apolipoprotein E3 mediate import and utilization of long-chain fatty acids as a metabolic fuel in neurons after glucose restriction.

The ability to oxidise hydrocarbons aerobically has been described in bacteria but not yet in archaea. Here, Leu et al. analyse metagenomic datasets from various environments and provide evidence supporting potential aerobic hydrocarbon oxidation ability in an archaeal lineage within the class Syntropharchaeia.

Gene deletions alter cellular physiology in complex and poorly understood ways. Here, authors present a machine learning strategy to predict the impact of metabolic gene deletions, offering top predictive accuracy for gene essentiality across varied organisms and adaptable to many other phenotypes.

PKM2 succinylation shifts boar sperm metabolism from glycolysis to PPP, enhancing mitochondrial activity, ATP production, and sustained linear motility.

Intracellular α-ketoglutarate availability dictates energy sensing through regulation of TET–YBX1-dependent AMP-activated protein kinase synthesis, which prevents disulfide stress accumulation and cell death in cancer cells.

Cellular metabolism produces reactive metabolites as both main and side products, requiring recycling pathways to detoxify these products. A study uncovers a recycling pathway that protects vitamin B₁₂ from inactivating covalent modification.

Marinda Westerveld and Rita Petracca describe the current understanding of the biosynthesis of crotonyl-coenzyme A.

Genetically encoded tools to manipulate redox metabolism are in high demand for investigating the underlying mechanism of cofactor imbalances in mammalian systems. A new tool enables the induction and interrogation of NADH reductive stress.