Article
|
Open Access
Featured
-
-
Article
| Open AccessLIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling
Kavšek et al. reveal in this C. elegans study that the LIN-39 and DAF-16 transcription factors cooperate to regulate enhancer activity in VC neurons and ensure proper neuron maturation. This in turn is required for longevity under reduced IIS conditions, linking chromatin dynamics to lifespan extension.
- Alan Kavšek
- , Jérôme Salignon
- & Christian G. Riedel
-
Article
| Open AccessPhase separated condensates of ATRX regulate neural progenitor identity
Tomooka et al. demonstrate that phase-separated ATRX condensates play an essential role in maintaining human neural progenitor identity through chromatin regulation and transcriptional control.
- Ryo Tomooka
- , Tsukasa Sanosaka
- & Jun Kohyama
-
Article
| Open AccessEarly developmental origins of cortical disorders modeled in human neural stem cells
The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerability phases during early human corticogenesis.
- Xoel Mato-Blanco
- , Suel-Kee Kim
- & Nicola Micali
-
Article
| Open AccessAxon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling
Pioneer neurons extend their axons to provide a track for follower neurons to follow, whether these neurons differ in other ways has not been clear. Here they show that pioneer and follower neurons are transcriptionally distinct and that RA signaling is required for pioneer axon targeting.
- Benjamin M. Woodruff
- , Lauren N. Miller
- & Alex V. Nechiporuk
-
Article
| Open AccessRFC1 regulates the expansion of neural progenitors in the developing zebrafish cerebellum
RFC1 is a replication and repair protein, and mutations to this gene are associated with rare movement disorders like late-onset cerebellar ataxias. Here they show that RFC1 is essential for zebrafish cerebellar development by preserving genome integrity in neural progenitors during neurogenesis.
- Fanny Nobilleau
- , Sébastien Audet
- & Éric Samarut
-
Article
| Open Accessα7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
The role of nicotinic acetylcholine receptors in human cortical development remains largely unexplored. Here authors investigate CHRNA7 and CHRFAM7A, uncovering their involvement in radial glial cell proliferation and neuronal differentiation, and identify YAP1 as a downstream effector of cholinergic signaling.
- Tanzila Mukhtar
- , Clara-Vita Siebert
- & Arnold R. Kriegstein
-
Article
| Open AccessHDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease
The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.
- Byung Jo Choi
- , Ju Yeon Hong
- & Hee Kyung Jin
-
Article
| Open AccessThe patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome
FOXG1 syndrome phenotypes depends largely on mutation type. Here authors generate a mouse model carrying the patient-specific Q84 mutation and report the N-terminal fragment produced, modifies the intracellular localization of FOXG1, and promotes radial glia identity while suppressing migration.
- Shin Jeon
- , Jaein Park
- & Soo-Kyung Lee
-
Article
| Open AccessAltered extracellular matrix structure and elevated stiffness in a brain organoid model for disease
Brain tissue mechanics influence development and disease. Here, the authors show that LIS1 mutations increase stiffness in human brain organoids due to ECM alterations and that targeted ECM modulation restores mechanical properties.
- Maayan Karlinski Zur
- , Bidisha Bhattacharya
- & Orly Reiner
-
Article
| Open AccessA differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification
Studying cilia in human neural development is key to understanding ciliopathies. Here, using stem cell-derived human and mouse spinal organoids, the authors reveal inter-species differences for ciliopathy genes and a role for cilia in human axial patterning.
- Antonia Wiegering
- , Isabelle Anselme
- & Aline Stedman
-
Article
| Open AccessDscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition
Cone photoreceptors form a regular mosaic pattern in vertebrate retina. The authors report that Down Syndrome Cell Adhesion Molecule (DSCAM) mediates homotypic recognition and self-avoidance between the same cone type, leading to cone mosaic spacing.
- Dongpeng Hu
- & Ichiro Masai
-
Article
| Open AccessSpatiotemporally resolved transcriptomics reveals the cellular dynamics of human retinal development
The cellular organization of retinal development is biologically complex. Here, the authors use spatial transcriptomics to analyse developing human retina providing insights into spatiotemporal expression signatures and cellular communication during retinogenesis
- Jinglong Zhang
- , Jiao Wang
- & Xing-Ming Zhao
-
Article
| Open AccessCerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity
The capacity of the brain to compensate for insults during development depends on the type of cell loss. Here authors reveal that embryonic ablation of cerebellar output neurons leads to powerful compensation by extra-cerebellar circuits, whereas mutations (En1/2) disrupt extra-cerebellar circuits regulating non-motor behaviors.
- Andrew S. Lee
- , Tanzil M. Arefin
- & Alexandra L. Joyner
-
Article
| Open AccessFoxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development
Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competition ensures robust vertebrate development and tissue patterning.
- Kanako Matsumoto
- , Yuki Akieda
- & Tohru Ishitani
-
Article
| Open AccessRoles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation
Loss of an snoRNA causes the neurodevelopmental disease Prader-Willi Syndrome (PWS). Here the authors generate snoRNA-deleted pre-neuronal cell lines. Small numbers of RNAs and proteins were altered, with functions potentially linked to PWS symptoms.
- Aleksandra Helwak
- , Tomasz Turowski
- & David Tollervey
-
Article
| Open AccessHOX gene expression in the developing human spine
The HOX gene cluster is responsible for anteroposterior axis patterning in an evolutionarily conserved manner. Here they examine HOX gene expression in human embryos and show that neural-crest derivatives retain the anatomical HOX code of their origin while also adopting the code of their destination.
- John E. G. Lawrence
- , Kenny Roberts
- & Sam Behjati
-
Article
| Open AccessRegional patterns of human cortex development correlate with underlying neurobiology
The neurobiology of human brain development and aging is hard to study in vivo. The authors report on distinct spatial associations between brain morphology and cellular as well as molecular brain properties throughout neurodevelopment and aging.
- Leon D. Lotter
- , Amin Saberi
- & Juergen Dukart
-
Article
| Open AccessSuppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development
Neuronal development is tightly controlled by nutrients and antioxidants. Here, authors show that ferroptosis, a cell death modality driven by lipid peroxidation, is required to be suppressed by vitamin A or antioxidants to ensure proper neuronal development.
- Juliane Tschuck
- , Vidya Padmanabhan Nair
- & Kamyar Hadian
-
Article
| Open AccessDevelopmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress
Here the authors show that the patterning signals WNT, BMP, and FGF control chromosome segregation fidelity during early lineage specification and neurogenesis, which could provide a rationale for the spatio-temporal distribution of genomic mosaicism during human development.
- Anchel de Jaime-Soguero
- , Janina Hattemer
- & Sergio P. Acebrón
-
Article
| Open AccessGalectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning
How Draper activates phagocytosis is not well understood. Here, the authors show that two Drosophila galectins, Hdg and Ctg, are secreted from hemocytes after dendrite injury and bridge phosphatidylserine and Draper to active phagocytosis.
- Hsin-Ho Sung
- , Hsun Li
- & Cheng-Ting Chien
-
Article
| Open AccessSynergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc
The authors show that synergistic activation by two transcription factors - Pointed, which is activated by cell–cell signaling, and Glass, which is eye-specific - drives a program of neuronal gene expression in developing Drosophila photoreceptors.
- Hongsu Wang
- , Komal Kumar Bollepogu Raja
- & Jessica E. Treisman
-
Article
| Open AccessMotor innervation directs the correct development of the mouse sympathetic nervous system
How tissues interact to help each other grow is a major question for biologists. Here, the authors show that motor innervation controls positioning of sympathetic progenitor cells to ensure correct shaping of ganglia in the peripheral nervous system.
- Alek G. Erickson
- , Alessia Motta
- & Igor Adameyko
-
Article
| Open AccessSingle cell dual-omic atlas of the human developing retina
The authors build an atlas of the human retinal development, using approximately 220,000 nuclei from 14 embryos and fetuses (8–23 weeks post-conception). The study reveals major cell classes, key transcription factors, and differences in the development of macular and peripheral retina.
- Zhen Zuo
- , Xuesen Cheng
- & Rui Chen
-
Article
| Open AccessAdult neurogenesis improves spatial information encoding in the mouse hippocampus
Adult neurogenesis is a unique form of neuronal plasticity, involving the genesis and integration of newborn neurons into the mouse dentate gyrus. Here the authors demonstrate that adult neurogenesis improves representations of space in the dentate gyrus by increasing the place-specific responses of mature neurons.
- M. Agustina Frechou
- , Sunaina S. Martin
- & J. Tiago Gonçalves
-
Article
| Open AccessOrb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation
Messenger RNAs (mRNAs) harboring rare codons are upregulated in the Drosophila brain. In this study, the authors demonstrate that such rare codon mRNAs are present in Drosophila neurons but not in neuroblast cells, and that Orb2 positively regulates rare-codon-dependent mRNA stability in neurons.
- Rebeccah K. Stewart
- , Patrick Nguyen
- & Donald T. Fox
-
Article
| Open AccessTraumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
TBI patients may develop long-term cognitive issues and neurodegenerative diseases. Here, the authors show that TBI induces structural changes in the mouse hippocampus by promoting neurogenesis at the cost of astrogliogenesis, and cellular dysplasia.
- P. Bielefeld
- , A. Martirosyan
- & C. P. Fitzsimons
-
Article
| Open Accessm5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis
Here, the authors identify MeCP2 as a cytosine methylated RNA reader protein that binds directly to m5C modified lncRNA lnRncr3 to maintain the neural progenitor pool and to block the processing of the embedded miR124a to limit neuronal differentiation.
- Jing Zhang
- , Huili Li
- & Lee A. Niswander
-
Article
| Open AccessDan forms condensates in neuroblasts and regulates nuclear architecture and progenitor competence in vivo
The genome is actively organized in progenitors to regulate their capacity to produce different cell types. Here, the authors show that a nuclear architecture protein forms condensates and controls the physical location of the genomic locus of a key competence transcription factor.
- Gillie Benchorin
- , Richard Jangwon Cho
- & Minoree Kohwi
-
Article
| Open AccessProtein translation rate determines neocortical neuron fate
Here the authors demonstrate how protein translation, controlled by Ire1α, regulates neuronal diversification in the developing neocortex.
- Ekaterina Borisova
- , Andrew G. Newman
- & Mateusz C. Ambrozkiewicz
-
Article
| Open AccessImplication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature
The role of subcellular thermogenesis during neuronal differentiation remains poorly understood. Here, the authors employ methods to monitor local intracellular temperature, and they investigate the effects of non-invasive temperature changes on cell differentiation using neuron-like cells.
- Shunsuke Chuma
- , Kazuyuki Kiyosue
- & Yoshie Harada
-
Article
| Open AccessNoncanonical function of folate through folate receptor 1 during neural tube formation
Neural tube defects are common birth defects that have been shown to be reduced through periconceptional folate supplementation, though the mechanism for this effect is unclear. Here they show that FOLR1 is necessary for neural tube formation in human neural organoids and Xenopus laevis embryos, and that this role is independent of its folate transport function.
- Olga A. Balashova
- , Alexios A. Panoutsopoulos
- & Laura N. Borodinsky
-
Article
| Open AccessDevelopmental basis of SHH medulloblastoma heterogeneity
The role of developmental pathways in medulloblastoma tumours (MB) with sonic hedgehog (SHH) activation remains to be explored. Here, the authors perform multi-omic analysis and characterise the key transcriptomic and metabolic patterns of highly differentiated cells in SHH MBs.
- Maxwell P. Gold
- , Winnie Ong
- & Ernest Fraenkel
-
Article
| Open AccessCommon and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
The molecular mechanisms controlling injury-dependent neuronal regeneration are largely unknown. Here, the authors use integrated multiomic analysis to characterize gene regulatory networks controlling injury-induced neurogenesis in zebrafish retina
- Pin Lyu
- , Maria Iribarne
- & Seth Blackshaw
-
Article
| Open AccessMechanical control of neural plate folding by apical domain alteration
Theoretical and experimental observations argue that apical domain heterogeneity in the neural plate is a tug-of-war contest between constricted and elongated cells. This competition likely reflects mechanical forces operating during tissue bending.
- Miho Matsuda
- , Jan Rozman
- & Sergei Y. Sokol
-
Article
| Open AccessKDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors
Zhang et al. report that KDM2B-∆CxxC activated Wnt signaling in the developing hippocampi, where the migration and differentiation of neural progenitors were blocked. KDM2B-∆CxxC mice exhibited defects of hippocampal morphology and related behaviors.
- Bo Zhang
- , Chen Zhao
- & Yan Zhou
-
Article
| Open AccessSubventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke
The functions of newborn cells arising from the subventricular zone in response to stroke have been unclear. Here, the authors show that cells migrating from the subventricular zone after stroke promote brain repair and functional recovery in mice.
- Michael R. Williamson
- , Stephanie P. Le
- & Michael R. Drew
-
Article
| Open AccessNon-uniform temporal scaling of developmental processes in the mammalian cortex
Marsupial mammals take much longer to develop than similarly sized placental mammals, though how brain development occurs across these different periods is unclear. Here they show that the neurodevelopmental events of cortical neurogenesis, cell migration and axon extension do not all temporally scale to the same extent.
- Annalisa Paolino
- , Elizabeth H. Haines
- & Laura R. Fenlon
-
Article
| Open AccessPlatelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
Exercise has positive effects on the brain during aging. Here the authors show that in mice, platelet-released exerkine PF4 mediates the effects of exercise on the brain.
- Odette Leiter
- , David Brici
- & Tara L. Walker
-
Article
| Open AccessNvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
Endodermal neurogenesis is an uncommon trait among animals. Here they identify a population of endoderm-specific neural progenitor cells in the cnidarian Nematostella vectensis that is characterized by the expression of the transcription factor prdm14d.
- Quentin I. B. Lemaître
- , Natascha Bartsch
- & Fabian Rentzsch
-
Article
| Open AccessSNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development
The balance of stem cell maintenance, differentiation, and programmed death is critical for proper development. Here they show that SNIP1 is critical for stem cell survival and differentiation in the developing brain where it acts downstream of TGFb and NFkB and regulates PRC2 activities for governing cell fates.
- Yurika Matsui
- , Mohamed Nadhir Djekidel
- & Jamy C. Peng
-
Article
| Open AccessSpatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey
Proteomic data covering fetal and neonatal primate brain development in the primate brain is needed to understand development and changes in functional gene products. Here, the authors show the dynamic proteomic changes of the cynomolgus macaque brain during the development from early fetal to neonatal stages by constructing a spatiotemporal proteomic atlas.
- Jingkuan Wei
- , Shaoxing Dai
- & Wei Si
-
Article
| Open AccessBalanced SET levels favor the correct enhancer repertoire during cell fate acquisition
The usage of specific distal regulatory regions within the genome is critical for fate specification and cell maturation. Here, the authors show that the accumulation of the oncoprotein SET, as occurring in the rare Schinzel-Giedion syndrome, and associated histone hypo-acetylation interfere with normal enhancer repertoire employed during brain development.
- Mattia Zaghi
- , Federica Banfi
- & Alessandro Sessa
-
Article
| Open AccessAsymmetric activity of NetrinB controls laterality of the Drosophila brain
Brain asymmetry is widespread across species, but its function remains poorly understood. Here, the authors show that the Netrin axon guidance pathway is involved in building an asymmetric neural circuit important for long-term memory in Drosophila.
- F. Lapraz
- , C. Boutres
- & S. Noselli
-
Article
| Open AccessRedox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.
- Weam S. Shahin
- , Shima O. Ebed
- & John F. Engelhardt
-
Article
| Open AccessPost-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis
Here the authors identify RNA-binding protein MEX3A as a post-transcriptional regulator of quiescence and differentiation signatures at critical transitions along the murine subependymal neurogenic lineage
- Ana Domingo-Muelas
- , Pere Duart-Abadia
- & Isabel Fariñas
-
Article
| Open AccessCBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder
Rubinstein-Taybi syndrome (RSTS) is a neurodevelopmental disorder with unclear underlying mechanisms. Here, the authors unravel the contribution of a stress-responsive pathway to RSTS where impaired HSF2 acetylation, due to RSTS-associated CBP/EP300 mutations, alters the expression of neurodevelopmental players, in keeping with hallmarks of cell-cell adhesion defects.
- Aurélie de Thonel
- , Johanna K. Ahlskog
- & Valérie Mezger
-
Article
| Open AccessImmature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb
New olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb circuits throughout life. Here, the authors show that immature OSNs provide behaviourally relevant sensory input to olfactory bulb neurons that is functionally distinct from that provided by mature OSNs.
- Jane S. Huang
- , Tenzin Kunkhyen
- & Claire E. J. Cheetham
-
Article
| Open AccessMTG8 interacts with LHX6 to specify cortical interneuron subtype identity
There is a large diversity of inhibitory interneurons in the mammalian cerebral cortex. How this emerges during embryogenesis remains unclear. Here, the authors identify MTG8 as a co-factor of LHX6 and a new regulator of cortical interneuron development.
- Zeinab Asgarian
- , Marcio Guiomar Oliveira
- & Nicoletta Kessaris
-
Article
| Open AccessWireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks
Traumatic brain injury can cause long-term disability and thus constitutes a substantial healthcare burden worldwide. Here, the authors report a conductive microporous hydrogel to improve angiogenesis and recovery of brain function in traumatic brain lesions.
- Ru-Siou Hsu
- , Ssu-Ju Li
- & Shang-Hsiu Hu