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mRNA quality control pathways in Saccharomyces cerevisiae

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Abstract

Efficient production of translation-competent mRNAs involves processing and modification events both in the nucleus and cytoplasm which require a number of complex machineries at both co-transcriptional and post-transcriptional levels. Mutations in the genomic sequence sometimes result in the formation of mutant non-functional defective messages. In addition, the enormous amounts of complexities involved in the biogenesis of mRNPs in the nucleus very often leads to the formation of aberrant and faulty messages along with their functional counterpart. Subsequent translation of these mutant and defective populations of messenger RNAs could possibly result in the unfaithful transmission of genetic information and thus is considered a threat to the survival of the cell. To prevent this possibility, mRNA quality control systems have evolved both in the nucleus and cytoplasm in eukaryotes to scrutinize various stages of mRNP biogenesis and translation. In this review, we will focus on the physiological role of some of these mRNA quality control systems in the simplest model eukaryote Saccharomyces cerevisiae.

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Abbreviations

CBC:

cap-binding complex

DRN:

decay of mRNA in the nucleus

NGD:

no-go delay

NMD:

nonsense-mediated decay

NPC:

nuclear pore complex

NSD:

non-stop decay

PTC:

premature termination codon

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Acknowledgements

Research work at author’s laboratory is funded by research grant from Council of Scientific and Industrial Research (Ref. No 38/1280/11/EMR-II), Department of Science and Technology (File No. SR/SO/BB/0066/2012) and a Research Grant from Jadavpur University to BD and from Department of Science and Technology, India, to SD (SR/WOS-A/LS-258/2010).

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  1. Department of Life Science and Biotechnology, Jadavpur University, Kolkata, 700 032, India

    Satarupa Das & Biswadip Das

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  1. Satarupa Das
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  2. Biswadip Das
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Correspondence to Biswadip Das.

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Corresponding editor: SUDHA BHATTACHARYA

MS received 12 December 2012; accepted 02 May 2013

Corresponding editor: Sudha Bhattacharya

[Das S and Das B 2013 mRNA quality control pathways in Saccharomyces cerevisiae. J. Biosci. 38 1–26] DOI 10.1007/s12038-013-9337-4

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Das, S., Das, B. mRNA quality control pathways in Saccharomyces cerevisiae . J Biosci 38, 615–640 (2013). https://doi.org/10.1007/s12038-013-9337-4

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