Discovering Biological Progression Underlying Microarray Samples
Figure 5
SPD applied to a prostate cancer dataset and derived a tree structure that describes the underlying progression.
(a) Nodes were color-coded according to their classification: normal, normal adjacent to tumor (NAP), tumor, metastatic samples (Mets). In (b), (c) and (d), nodes were color-coded using the average expression of modules 2, 32 and 19, respectively, in order to show how the expression of these modules gradually change during the progression.