A Compartment Model of VEGF Distribution in Humans in the Presence of Soluble VEGF Receptor-1 Acting as a Ligand Trap
Figure 10
Steady-state Effects of Plasma Clearance Rate (kCL) on VEGF and sVEGFR1 Concentrations.
Increasing kCL resulted in: (i) drastically lower plasma concentrations of both free VEGF and sVEGFR1, (ii) lower interstitial sVEGFR1 but unchanged interstitial VEGF, and (iii) reduced transendothelial gradient for VEGF but not for sVEGFR1.