Diversity of Intrinsic Frequency Encoding Patterns in Rat Cortical Neurons—Mechanisms and Possible Functions
Figure 1
(A) Infrared differential interference contrast photograph of a whole-cell patch-clamp recording from a regular-spiking pyramidal neuron: stimulation and recording are carried out through the pipette on the soma. Below: recorded membrane potential (black) filtered with a Gaussian digital filter when injected constant current (pink) is 300 pA (left) and −100pA (right). (B) Average tuning curves of neurons when the offset values of the injected stimuli varies. The output spiking rate is a decreasing function of the input frequency (blue) when stimuli were of relatively small offset magnitude, and the neuron's firing rate was steady (red) or even increasing (green) for stimuli with larger offset. (C) Membrane potential with sinusoidal current injection (pink) of different frequencies of 10, 30 and 50 Hz, respectively (blue: decreasing, red: flat, and green: increasing).