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The Yin and Yang of Yeast Transcription: Elements of a Global Feedback System between Metabolism and Chromatin

Figure 3

Cluster transcriptome meta-analysis & ATP:ADP ratio.

3A: Relative RNA expression profiles of redox clusters (rows) in a collection 1,327 microarray hybridization datasets [60] (columns). The normalized rank sum indicates a bias of the cluster genes towards upregulation (, red to yellow) or downregulation (, cyan to blue) in the respective experiment. Experiments were sorted into 5 clusters (column numbers) by the SOTA algorithm [104] and plotted in decreasing order (from left to right) of the means of cluster A’s values. The Dataset S3 gives SOTA assignments, values and p-values from two-sided Mann-Whitney-Wilcoxon tests. 3B: The ATP:ADP ratio was measured enzymatically every 5 minutes over three cycles of a respiratory oscillation and culture system that corresponds to the 0.7 h period dataset (available as Dataset S8).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0037906.g003