Increased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression
Figure 6
PITX2 promotes the tumor growth in nude mice.
(A) PITX2 stably expressing clones in SKOV3 (C4 and C5) showed faster in the tumor growth in nude mice as compared with the vector control. The tumor size was represented by the mean ± SE of five mice and was measured for 36 days.*, P<0.01, significantly different from vector control group. (B) Photograph illustrates the dissected tumors taken from nude mice subcutaneously injected by two PITX2 stable expressing clones in SKOV3 (C4 and C5) and the vector control on Day 36. (C) Western blot analysis showed the expressions of PITX2, Cyclin-D1 and C-myc from the mice subcutaneous tumor tissues. The numerical value under each panel represents the relative expression of Cyclin-D1 and C-myc to their vector controls.