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DNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant

Figure 4

Association of Locus-specific DNA methylation to aGVHD.

(A) IFNγ methylation up to 12 months post-transplant is shown in the left panel. The black line marked the mean value in the cohort and the dotted line marked the mean value 1 month post-HCT. In the central panel are represented IFNγ methylation values according to severity of aGVHD 1 month post-HCT. IFNγ ROC curve for patients with severe aGVHD versus non-aGVHD and moderate aGVHD (AUC = 0.782) is shown in the right panel. (B) FASL methylation up to 12 months post-transplant and methylation values according to severity of aGVHD 1 month post-HCT. FASL ROC curve for patients with severe aGVHD versus non-aGVHD and moderate aGVHD (AUC = 0.769) is shown in the right panel. (C) IL-10 methylation up to 12 months post-transplant and methylation values according to severity of aGVHD 1 month post-HCT. IL-10 ROC curve for patient with and without aGVHD (AUC = 0.764) is shown in the right panel. (D) PRF1 methylation up to 12 months post-transplant and methylation values according to severity of aGVHD 1 month post-HCT.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0056931.g004