Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway
Figure 1
Changes in metabolites within (A) tryptophan, (B) tyrosine and (C) purine metabolism pathways.
Abbreviations: HIOMT = hydroxyindole-O-methyltransferase; 5-HIAD = 5-Hydroxyindole acetyldehyde; NM-5-HT = N-methyl serotonin; 5-HTPOL = 5-Hydroxytryptophol; 5-MIAA = 5-Methoxyindole acetic acid; 5-MTPM = 5-methoxytryptamine. For the remaining metabolites, see Table 1.