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Immature rotavirus particles

Representation of a frozen-hydrated solution of immature rotavirus particles, illustrating the architecture of the virion prior to proteolytic activation. Rendered visualization based on atomic models from cryo-EM reconstructions of the non-trypsinized spike and triple-layered particle (PDB IDs: 8OLE and 8OLB) described in the manuscript by Asensio-Cob D et al (2025). Structural determinants of rotavirus proteolytic activation.

Image Credit: Daniel Luque

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