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A novel gene expression stability metric to unveil homeostasis and regulation Mengjie Chen Method Open access 10 October 2025 Article: 351
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A molecular census to elucidate the demixing mechanism of membraneless organelles Cheryn AliFernando MuzzopappaFabian Erdel Research Open access 09 October 2025 Article: 347
Engineered virus-like particle-assembled Vegfa-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration Jun WuHyewon JangJeong Hun Kim Research Open access 09 October 2025 Article: 346
Multi-omics insights into microbiome-rumen epithelium interaction mechanisms underlying subacute rumen acidosis tolerance in dairy goats Jingyi XuXiaodong ChenShengru Wu Research Open access 09 October 2025 Article: 345
Pan-S-locus analysis reveals insights into the origin and evolution of self-incompatibility in the orange subfamily Jianbing HuZezhen DuLijun Chai Research Open access 07 October 2025 Article: 344
A ternary-code DNA methylome atlas of mouse tissues Sol Moe LeeDavid C. GoldbergWanding Zhou Research Open access 07 October 2025 Article: 343
High-precision cell-type mapping and annotation of single-cell spatial transcriptomics with STAMapper Qunlun ShenKangning DongShihua Zhang Methodology Open access 07 October 2025 Article: 342
Structural and evolutionary features of red algal UV sex chromosomes Agnieszka P. LipinskaGuillaume CossardSusana M. Coelho Research Open access 07 October 2025 Article: 341
Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution Luzhang JiQihang ZouChenfei Wang Methodology Open access 06 October 2025 Article: 340
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Silent mutations in coding regions of Hepatitis C virus affect patterns of HCV RNA structures and attenuate viral replication and pathogenesis Roba DabourShaked BergmanTamir Tuller Research Open access 06 October 2025 Article: 338
A nucleoporin-associated signaling cascade controls plant immunity via histone modification Leiwen PanShun PengShui Wang Research Open access 06 October 2025 Article: 337
Potential synthetic associations created by epistasis Hai-Jun LiuJingxian FuMagnus Nordborg Brief Report Open access 06 October 2025 Article: 336
xCell 2.0: robust algorithm for cell type proportion estimation predicts response to immune checkpoint blockade Almog AngelLoai NaomDvir Aran Research Open access 03 October 2025 Article: 335
Biology-driven insights into the power of single-cell foundation models Jialu WuQing YeTingjun Hou Research Open access 03 October 2025 Article: 334
Unico: a unified model for cell-type resolution genomics from heterogeneous omics data Zeyuan Johnson ChenElior RahmaniEran Halperin Method Open access 03 October 2025 Article: 333
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GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density Mitchell ConeryJames A. PippinStruan F. A. Grant Research Open access 03 October 2025 Article: 331
Phase-separating fusion proteins drive cancer by upsetting transcription regulation Nazanin FarahiTamas LazarRita Pancsa Research Open access 02 October 2025 Article: 330
WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution Sohyun BangXuan ZhangRobert J. Schmitz Research Open access 02 October 2025 Article: 329
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DeepWheat: predicting the effects of genomic variants on gene expression and regulatory activities across tissues and varieties in wheat using deep learning Zhigang MaJiazi ZhangZefu Lu Methodology Open access 29 September 2025 Article: 321
Characterization of the transposable element landscape shaping the Ectocarpus genome Erica DinataleRory J. CraigSusana M. Coelho Research Open access 29 September 2025 Article: 320
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Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals Guillermo Palou-MárquezFran Supek Research Open access 29 September 2025 Article: 316
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation Lina WorpenbergCédric GobetFelix Naef Research Open access 27 September 2025 Article: 315
Hybrid BAG-seq: DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples Siran LiJoan AlexanderDan Levy Methodology Open access 27 September 2025 Article: 314
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Deciphering functional landscapes of rumen microbiota unveils the role of Prevotella bryantii in milk fat synthesis in goats Yu LeiYining ZhengKe Zhang Research Open access 26 September 2025 Article: 311
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SNPmanifold: detecting single-cell clonality and lineages from single-nucleotide variants using binomial variational autoencoder Hoi Man ChungYuanhua Huang Methodology Open access 26 September 2025 Article: 309
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