PLO CREAM COMPOUNDING INSTRUCTIONS
INFORMATION FOR THE PHARMACIST 5% PROMETHAZINE Using the
To make 100 grams of 5% PROMETHAZINE using the 1. Clean equipment with alcohol. 2. Weigh out 5 grams of PROMETHAZINE powder and place in a mixing vessel. 3. Make a paste by adding 5 mL of distilled water. Avoid using too much distilled water, as this will reduce the consistency of the final product. The paste may be slightly granular. 4. If Compound A has been cooled, it may be solid. Warming to room temperature will allow it to liquify for use. Compound B has the unusual property of solidifying at room temperature. To liquify, refrigerate prior to use. 5. Measure 71 mL until smooth. 6. Measure 24 mL Compound B and gradually add it to the PROMETHAZINE paste. Mix Compound A. Kit:
KIT
7. The final product can be made in an ointment jar. Add the Compound A to the Compound B / PROMETHAZINE mixture. Mix the two compounds until a thick cream is produced. 8. For clean-up, wipe equipment, rinse with cold water, and then wash with detergent. Note: kits are prepackaged in the proper lipophilic:hydrophilic ratio. If you need to make a different size prescription, use a ratio of one part Compound A (lipophilic) to three parts Compound B (hydrophilic). COMPOUND A AND COMPOUND B BEFORE USE?
HOW SHOULD I STORE
Both Compound A and Compound B are stable at room temperature. The kit can be kept intact at room temperature until use. Compound B is solid at room temperature, so it should be refrigerated prior to use to allow it to liquify. It may be more convenient to separate the components of the kit, storing Compound A at room temperature and keeping Compound B in the refrigerator. HOW DO I STORE THE FINAL PRODUCT? PROMETHAZINE in PLO gel should be stored at room temperature. Cooling may liquify the final product. If this occurs, further mixing can restore consistency. Shelf life of the PROMETHAZINE / product is six (6) months.
2012 Do not reproduce without permission.
PLO CREAM COMPOUNDING INSTRUCTIONS
INFORMATION FOR THE PHARMACIST 5% PROMETHAZINE Using
To make 100 grams of 5% PROMETHAZINE in 1. Clean equipment with alcohol. 2. Weigh out 5 grams of PROMETHAZINE powder and place in a mixing vessel. 3. Make a paste by adding 5 mL of distilled water. Avoid using too much distilled water, as this will reduce the consistency of the final product. The paste may be slightly granular. 4. Measure out required amount of pre-mixed cream (100 grams minus the weight of the drug). If the cream had previously been cooled, it may be partially liquid. Mixing will restore its proper consistency. 5. Mix the PROMETHAZINE paste into the ointment jar. cream. The final product can be made in the
PRE-MIXED CREAM
pre-mixed cream:
6. For clean-up, wipe equipment, rinse with cold water, and then wash with detergent.
HOW SHOULD I STORE
PRE-MIXED CREAM BEFORE USE?
pre-mixed cream is stable at room temperature and should be stored at room temperature. Cooling may liquify the pre-mixed cream. If this occurs, further mixing can restore consistency. HOW DO I STORE THE FINAL PRODUCT? PROMETHAZINE in PLO gel should be stored at room temperature. Cooling may liquify the final product. If this occurs, further mixing can restore consistency. Shelf life of the PROMETHAZINE / product is six (6) months.
COMMENTS OR QUESTIONS? CONTACT US AT: , 17208 108 Ave Edmonton, CANADA, T5S 1E8 PHONE: 1-888-MAXIMA8 (629-4628) FAX: (780) 434-8513 E-MAIL: [email protected] Visit our Website: www.diffusimax.com
2012 Do not reproduce without permission.
