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TLCR Annual Report 2025

Welcome to the 2025 annual report for Translational Lung Cancer Research. In 2025, the TLCR has continued its mission to increase the quality and impact of the journal, and to provide readers with a novel, well-organized, informative, enlightening and educational journal.

We would like to sincerely thank our Editorial Board Members, Guest editors, Reviewers, Authors, Readers for all your supports and contributions to TLCR in 2025, and we look forward to continuing our work with you in the new year.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

New Impact Factor for Translational Lung Cancer Research: 3.5

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has attained its latest impact factor update for the 2024 citation year: 3.5.

Translational Lung Cancer Research 2024 CiteScore Released: 6.9

We are pleased to announce that the Translational Lung Cancer Research (TLCR) has achieved its 2024 CiteScore: 6.9, ranking 92 out of 415 journals in the Oncology category. This milestone underscores our ongoing commitment to publishing impactful research in the field.

Interviews with Outstanding Authors (2025)

In 2025, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors, with a brief interview of their thoughts and insights as authors. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Reviewer of the Month (2025)

In 2025, TLCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Editorial Board Members

TLCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TLCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

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Vol 14, No 12 (December, 2025)

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Editorial Commentary

Ivonescimab: promise or reality for advanced non-small cell lung cancer?

Alejandro Olivares-Hernández, Pedro Gonzalez Santa-Catalina, Emilio Fonseca-Sánchez, Edel del Barco-Morillo

Translational Lung Cancer Research

2025;

(12)

:5203-5207

(31 December 2025)

PDF Full Text (108) Peer Review File COI Form Open Access

Original Article

Real-world outcomes of trastuzumab deruxtecan as second- or further-line treatment in patients with HER2-mutant metastatic non-small cell lung cancer: a retrospective study

Kuofang Huang, Zhihuang Hu, Shifei Pan, Jialin Qian, Xianghua Wu, Huijie Wang, Kai Wang, Haijiao Lu, Huishu Dong, Tianqing Chu, Jialei Wang

Translational Lung Cancer Research

2025;

(12)

:5208-5217

(31 December 2025)

PDF Full Text (190) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinical characteristics of post-operative N2 nodal upstaging in non-small cell lung cancer: a retrospective cohort study

Sun Young Choi, Myung Jin Song, Byung Soo Kwon, Yeon Wook Kim, Jong Sun Park, Sukki Cho, Jae Ho Lee, Choon-Taek Lee, Sung Yoon Lim

Translational Lung Cancer Research

2025;

(12)

:5218-5229

(31 December 2025)

PDF Full Text (85) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Computer-aided quantitative stromal analysis: a comprehensive investigation of its prognostic significance in lung squamous cell carcinoma

Xin Zhang, Jin Chen, Xiaodong Bu, Qitang Huang, Yuqing Li, Dan Zhang, Jun Yang, Anning Feng, Fanqing Meng, Wei Li, Qi Sun, Chun Xu

Translational Lung Cancer Research

2025;

(12)

:5230-5242

(31 December 2025)

PDF Full Text (108) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer

Xiaoliang Wang, Yujiao Ma, Ying Dong, Yanling Wang, Jupeng Yuan, Jinming Yu, Dawei Chen

Translational Lung Cancer Research

2025;

(12)

:5243-5256

(31 December 2025)

PDF Full Text (79) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Patient-reported outcomes of radiofrequency ablation-video-assisted thoracoscopic surgery (VATS) hybrid surgery vs. uniportal VATS for multiple primary lung nodules: a longitudinal cohort study

Ruifeng Xu, Guochao Zhang, Na Ren, Fanmao Meng, Tiejun Liu, Mengbai Tian, Mufei Sun, Hongrui Wang, Yitong Lu, Xin Liang, Yu Tian, Qi Xue, Xin Sun, Yun Che, Shugeng Gao, Liang Zhao

Translational Lung Cancer Research

2025;

(12)

:5257-5272

(31 December 2025)

PDF Full Text (70) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Additional 1.1-mm cryobiopsy trial guided by rapid on-site cytologic evaluation of touch imprint cytology result of small forceps biopsy in peripheral pulmonary lesions: a prospective single-center study

Yuki Takigawa, Ken Sato, Suzuka Matsuoka, Mayu Goda, Keisuke Shiraha, Takeru Ichikawa, Shoichiro Matsumoto, Tomoyoshi Inoue, Miho Fujiwara, Jun Nishimura, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Tetsuya Isoda, Yoko Shinno, Keiichi Fujiwara, Takuo Shibayama

Translational Lung Cancer Research

2025;

(12)

:5273-5282

(31 December 2025)

PDF Full Text (66) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Exon-level TP53 alterations and PD-L1 expression identified by pretreatment NGS stratify survival in EGFR-mutant non-small cell lung cancer treated with first-line osimertinib

Seong-Eun Kim, Yongjae Kim, Do Kyung Yoon, Hwan Park, Kang-Seo Park, Deokhoon Kim, Hee Sang Hwang, Bokyung Ahn, Ji Eun Park, Sang-We Kim, Se Jin Jang, Shinkyo Yoon, Ho-Su Lee, Dae Ho Lee

Translational Lung Cancer Research

2025;

(12)

:5283-5295

(31 December 2025)

PDF Full Text (109) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development of a multimodal fully automated ensemble model to predict EGFR mutation and efficacy of EGFR-TKI in non-small cell lung cancer

Shiting Xu, Taichi Miyawaki, Takehito Shukuya, Kazuhiro Suzuki, Shoko Sonobe Shimamura, Hironari Matsuda, Ryota Kanemaru, Tetsuhiko Asao, Tomoyasu Mimori, Yujiro Otsuka, Kazuhisa Takahashi

Translational Lung Cancer Research

2025;

(12)

:5296-5304

(31 December 2025)

PDF Full Text (82) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A systematic literature review and meta-analysis on the efficacy and safety of PD-(L)1 inhibitors for the first- and second-line treatment of locally advanced or metastatic non-small cell lung cancer in Asian and non-Asian patients

Nicolas Girard, Daniel Tan, Diego Cortinovis, Gilberto Lopes, Pei Jye Voon, Mesha Austin Taylor, Nadeem Ghali, Lin Zhan, Sheng Xu, Kirsha Naicker, Solange Peters

Translational Lung Cancer Research

2025;

(12)

:5305-5322

(31 December 2025)

PDF Full Text (125) Reporting Checklist Peer Review File COI Form Open Access

Radiotherapy vs. photodynamic therapy: a comparison of antitumor effects and pulmonary toxicity in preclinical models

Yoshihisa Hiraishi, Takamasa Koga, Hiroyuki Ogawa, Andrew Effat, Lili Ding, Juan Chen, Jonathan Allen, Takahiro Yanagihara, Fumi Yokote, Nicholas Bernards, Masato Aragaki, Kate Kazlovich, Nadia Mohammed, Tsukasa Ishiwata, Yusuke Fujibayashi, Akira Saito, Hidenori Kage, Jonathan Yeung, Gang Zheng, Kazuhiro Yasufuku

Translational Lung Cancer Research

2025;

(12)

:5323-5334

(31 December 2025)

PDF Full Text (123) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Evaluating cancer risk profiles in lung transplant recipients

Yanwei Lin, Jiaqin Zhang, Caikang Luo, Xin Xu, Yining Pan, Chao Yang, Guilin Peng, Xuanlin Zhang, Jie Zhang, Wenhua Liang, Jiang Shi, Jianxing He

Translational Lung Cancer Research

2025;

(12)

:5335-5346

(31 December 2025)

PDF Full Text (49) Reporting Checklist Peer Review File COI Form Open Access

Electromagnetic navigation bronchoscopy for localization of bilateral multiple pulmonary nodules: a comparative evaluation of safety and efficacy

Chudong Wang, Jianwei Gao, Rui Wang, Zijian Li, Dixuan Zhang, Zhihao Jiang, YenZhir Tay, Jianxing He, Shuben Li

Translational Lung Cancer Research

2025;

(12)

:5347-5356

(31 December 2025)

PDF Full Text (60) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Exploring perioperative treatment for non-small cell lung cancer patients harboring EGFR mutation: a real-world multicenter cohort study

Yu Zhou, Zihan Wei, Min Li, Juan Li, Rui Meng, Fang Wu, Guanming Jiang, Baihua Zhang, Bolin Chen, Chunhua Zhou, Wenjuan Jiang, Liang Zeng, Lin Wu, Xiang Yan, Xingxiang Pu

Translational Lung Cancer Research

2025;

(12)

:5357-5371

(31 December 2025)

PDF Full Text (58) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Completion lobectomy following segmentectomy for malignant lung tumors: a multi-institutional study of surgical feasibility, oncologic outcomes, and diagnostic challenges (ESSG-02 study)

Takuya Watanabe, Kosuke Fujino, Tadashi Sakane, Yoshinori Handa, Takefumi Doi, Natsuko Kawatani, Seshiru Nakazawa, Takahiro Iida, Ryutaro Hanawa, Shuichi Shinohara, Atsushi Ito, Masayuki Tanahashi

Translational Lung Cancer Research

2025;

(12)

:5372-5382

(31 December 2025)

PDF Full Text (66) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Metabolic tumor volume on ¹⁸F-fluorodeoxyglucose uptake as prognostic marker for osimertinib in patients with non-small cell lung cancer harboring sensitive EGFR mutation

Kosuke Hashimoto, Kyoichi Kaira, Hisao Imai, Atsuto Mouri, Ou Yamaguchi, Ichiei Kuji, Hiroshi Kagamu

Translational Lung Cancer Research

2025;

(12)

:5383-5392

(31 December 2025)

PDF Full Text (86) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Endocrine immune-related adverse events in advanced lung cancer patients receiving immune checkpoint inhibitors: incidence, predictors and outcomes

Yi Liu, Jiarui Zhang, Linhui Yang, Jiadi Gan, Huohuo Zhang, Qi Qi, Wanqin Fang, Junyi Zhu, Rui Xu, Xianya Hu, Yufang Xie, Sha Liu, Weimin Li, Dan Liu

Translational Lung Cancer Research

2025;

(12)

:5393-5404

(31 December 2025)

PDF Full Text (80) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognosis of segmentectomy and lobectomy for clinical T1c solid-dominant lung cancer

Ziyao Zhang, Fangqiu Fu, Xiangze Li, Yang Zhang, Haiquan Chen

Translational Lung Cancer Research

2025;

(12)

:5405-5414

(31 December 2025)

PDF Full Text (57) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development and validation of an interpretable machine learning model for prediction of occult lymph node metastasis in clinical stage T1 lung adenocarcinoma

Yuxing Chen, Jiahui Jin, Yihan Mao, Chengkai Zhou, Qingpeng Zeng, Jun Zhao

Translational Lung Cancer Research

2025;

(12)

:5415-5430

(31 December 2025)

PDF Full Text (88) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development and validation of machine learning models based on blood routine tests and tumor markers in early screening of primary bronchogenic lung cancer

Wenjing Deng, Lijuan Pan, Haolin Wang, Yulong Liu, Xuelian Peng, Chunyan Yang, Jin Li, Baoru Han

Translational Lung Cancer Research

2025;

(12)

:5431-5446

(31 December 2025)

PDF Full Text (110) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A lactylation-driven prognostic model for lung adenocarcinoma: cellular lactylation heterogeneity and immune insights

Ziheng Yang, Hui Cheng, Sheng Zhang, Fan Li, Bo Zhao

Translational Lung Cancer Research

2025;

(12)

:5447-5464

(31 December 2025)

PDF Full Text (65) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Real-world outcomes of first-line immunotherapy and subsequent systemic therapies in pleural mesothelioma: a multicenter study in China

Binhe Tian, Boyu Sun, Zixiang Zhou, Shuman Kuang, Jiongyuan Li, Weixuan Pan, Zhe Zhu, Xiaoyan Si, Li Zhang, Jun Liu, Juhong Shi, Fang Wu, Haitao Zhao, Hanping Wang

Translational Lung Cancer Research

2025;

(12)

:5465-5478

(31 December 2025)

PDF Full Text (128) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The effects of neoadjuvant sintilimab versus pembrolizumab combined with chemotherapy on resectable non-small cell lung cancer: a multicenter propensity score-matched study

Yichen Sun, Zhiyuan Gao, Zhilin Luo, Liping Tong, Yong Zhang, Xiaoping Dong, Junying Wang, Wenjing Li, Ziyi Li, Weiru Qiao, Xian Chen, Hongtao Duan, Xiaolong Yan

Translational Lung Cancer Research

2025;

(12)

:5479-5490

(31 December 2025)

PDF Full Text (55) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Circulating tumor DNA as prognostic markers of non-small cell lung cancer (NSCLC): a systematic review and meta-analysis

Xiaowei Chen, Meng Zhang, Qingxin Zhou, Nana Guo, Baoshan Cao, Hongmei Zeng, Wanqing Chen, Feng Sun

Translational Lung Cancer Research

2025;

(12)

:5491-5508

(31 December 2025)

PDF Full Text (160) Reporting Checklist Peer Review File COI Form Open Access

Review Article

Targeting ferroptosis to overcome drug resistance in lung cancer

Pengfei Sheng, Jiang Jin, Hao Liu, Cien Sun, Yutao Chen, Xin Chen, Dehua Ma, Jianfei Shen

Translational Lung Cancer Research

2025;

(12)

:5509-5526

(31 December 2025)

PDF Full Text (116) Peer Review File COI Form Open Access

Study Protocol

A study protocol of a single-arm, prospective, open-label, non-controlled, phase II study of neoadjuvant BL-B01D1 combined with aumolertinib in resectable stage II–IIIB non-small cell lung cancer patients with EGFR mutation

Yue Chen, Jiandong Mei, Ge Gao, Benxia Zhang, Yanying Li, Zhiyu Peng, Chuan Li, Fanyi Gan, Qiang Pu, Chengwu Liu, Wenjie Yang, Lunxu Liu, Yongsheng Wang

Translational Lung Cancer Research

2025;

(12)

:5527-5534

(31 December 2025)

PDF Full Text (74) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Diagnostic challenge of systemic amyloidosis mimicking EGFR-TKI toxicity in lung adenocarcinoma: a case report

So-yun Kim, Hyeong Seok Kang, Joo-Eun Lee, Hyun-Yi Kim, Min-Kyung Yeo, Chaeuk Chung

Translational Lung Cancer Research

2025;

(12)

:5535-5544

(31 December 2025)

PDF Full Text (62) Reporting Checklist Peer Review File COI Form Open Access

Erratum

Erratum: Navigation of video-assisted thoracoscopic surgery using electromagnetic versus CT-guided localization (NOVEL): a study protocol for comparing procedural success and complication rates in a prospective, multicenter, randomized controlled, non-inferiority phase III trial

Editorial Office

Translational Lung Cancer Research

2025;

(12)

:5545-5546

(31 December 2025)

PDF Full Text (32) Open Access

Review Articles

Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 22 October 2013

PDF Full Text (339041) Open Access

Editorial Commentary

Ground glass nodules with 5 years’ stability can grow after 10-year follow-up: do genetic features determine the fate?

Yoshihisa Kobayashi, Tetsuya Mitsudomi

Published online: 31 December 2019

PDF Full Text (88869) Open Access

Review Article

Non-small cell lung cancer: current treatment and future advances

Cecilia Zappa, Shaker A. Mousa

Published online: 30 June 2016

PDF Full Text (80180) Open Access

Review Articles

Irreversible EGFR-TKIs: dreaming perfection

Lorenza Landi, Federico Cappuzzo

Published online: 14 January 2013

PDF Full Text (70465) Open Access

Review Article

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song, written on behalf of the AME Lung Cancer Collaborative Group

Published online: 28 February 2017

PDF Full Text (60944) Open Access

Review Article

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Published online: 28 August 2014

PDF Full Text (48581) Open Access

Review Article

Treatment of uncommon EGFR mutations in non-small cell lung cancer: new evidence and treatment

Tianli Zhang, Bing Wan, Yuan Zhao, Chuling Li, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song

Published online: 30 June 2019

PDF Full Text (45601) Open Access

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future

Bryan A. Chan, Brett G.M. Hughes

Published online: 24 February 2015

PDF Full Text (43696) Open Access

Review Article

Lung cancer prediction using machine learning and advanced imaging techniques

Timor Kadir, Fergus Gleeson

Published online: 14 June 2018

PDF Full Text (43064) Open Access

Review Article

Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights

Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi

Published online: 28 August 2018

PDF Full Text (41753) Chinese (6249) Open Access

Review Article

The past, present and future of immunotherapy against tumor

Tao Jiang, Caicun Zhou

Published online: 24 June 2015

PDF Full Text (39643) Open Access

Review Article

The epidemiology of lung cancer

Patricia M. de Groot, Carol C. Wu, Brett W. Carter, Reginald F. Munden

Published online: 14 June 2018

PDF Full Text (34890) Open Access

Review Article

Lung cancer screening: nodule identification and characterization

Ioannis Vlahos, Konstantinos Stefanidis, Sarah Sheard, Arjun Nair, Charles Sayer, Joanne Moser

Published online: 14 June 2018

PDF Full Text (33959) Open Access

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Published online: 11 October 2017

PDF Full Text (32769) Open Access

Review Articles

KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach

Javier de Castro Carpeño, Cristóbal Belda-Iniesta

Published online: 03 April 2013

PDF Full Text (32519) Open Access

Review Article

Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey

Jeffrey P. Gregg, Tianhong Li, Ken Y. Yoneda

Published online: 30 June 2019

PDF Full Text (32531) Open Access

Consensus

Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)

Jianxing He, Hengrui Liang, Wei Wang, Andrey Akopov, Alberto Aiolfi, Keng-Leong Ang, Luca Bertolaccini, Kaican Cai, Qingdong Cao, Baojun Chen, Chang Chen, Chun Chen, Donglai Chen, Fengxia Chen, Jun Chen, Lei Chen, Mingwu Chen, Yongbing Chen, Zhuxing Chen, Chao Cheng, Dong Cui, Fei Cui, Tianyang Dai, Qinglong Dong, Paolo A. Ferrari, Raja M. Flores, Junke Fu, Soichiro Funaki, Marios E. Froudarakis, Xiangfeng Gan, Mingfei Geng, Jialong Guo, Qiang Guo, Yongtao Han, Jintao He, Kaiming He, Kyoji Hirai, Jian Hu, Shuqiao Hu, Jian Huang, Jun Huang, Wenfa Jiang, Kyung Soo Kim, Gabor Kiss, Fanyi Kong, Lan Lan, Xuefeng Leng, Bin Li, Gaofeng Li, Hecheng Li, Hefei Li, Heng Li, Jiwei Li, Xiaoqiang Li, Shuben Li, Yinfen Li, Zhuoyi Li, Yi Liang, Lixia Liang, Wenhua Liang, Yongde Liao, Wanli Lin, Xu Lin, Hongxu Liu, Hui Liu, Jixian Liu, Jun Liu, Xiang Liu, Zihao Liu, Xingzhao Lu, Qingquan Luo, Naiquan Mao, Qi Pan, Dazhi Pang, Jun Peng, Jun Peng, Eugenio Pompeo, Rulin Qian, Kun Qiao, Bassam Redwan, Zi Sang, Wenlong Shao, Jianfei Shen, Weiyu Shen, Sook-Whan Sung, Wenfang Tang, Tianhu Wang, Guangsuo Wang, Haitao Wang, Huien Wang, Jiyong Wang, Wen Wang, Yongyong Wang, Zhenyuan Wang, Li Wei, Wei Wei, Hao Wu, Jie Wu, Zhaohua Xia, Chenyang Xu, Enwu Xu, Hai Xu, Ning Xu, Quan Xu, Rongyu Xu, Shun Xu, Chaokun Yang, Hanyu Yang, Shengli Yang, Jun Yi, Guangjian Zhang, Hao Zhang, Jia Zhang, Man Zhang, Xiao Zhang, Yajie Zhang, Zhe Zhang, Zhifeng Zhang, Honglin Zhao, Jian Zhao, Xiaodong Zhao, Jianping Zhou, Yanran Zhou, Chengchu Zhu, Shaojin Zhu, Xinhai Zhu, Jian Cui, Yubo Yan, Ke-Neng Chen

Published online: 28 August 2021

PDF Full Text (30912) COI Form Open Access

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Published online: 19 April 2015

PDF Full Text (29824) Open Access

Review Articles

Angiogenesis in cancer: anti-VEGF escape mechanisms

Gerald W. Prager, Marina Poettler, Matthias Unseld, Christoph C. Zielinski

Published online: 18 February 2012

PDF Full Text (29158) Open Access

Review Articles

New TNM classification: achievements and hurdles

Peter Goldstraw

Published online: 17 August 2013

PDF Full Text (29071) Open Access

Full Most Read article list >>

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis

Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song

BRAF mutations in non-small cell lung cancer

Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper

The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer

Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper

Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice

Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song

Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer

Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song

Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer

Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants

Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden

The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices

Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer

Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto

Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement

Hyojin Kim, Jin-Haeng Chung

Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer

Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu

Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review

Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao

Clinical trials for lung cancer in China

Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu

Recurrence after surgery in patients with NSCLC

Hidetaka Uramoto, Fumihiro Tanaka

Prognostic markers in lung cancer: is it ready for prime time?

Chang-Qi Zhu, Ming-Sound Tsao

Potential biomarkers for lung cancer screening

Gabriella Sozzi, Mattia Boeri

Particle therapy in non-small cell lung cancer

Zhongxing Liao, Charles B. Simone II

Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions

Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai

Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer

Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft

Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors

Suchit H. Patel, Andreas Rimner, Roger B. Cohen

Intraoperative near-infrared imaging of mesothelioma

Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal

BAP1, a tumor suppressor gene driving malignant mesothelioma

Mitchell Cheung, Joseph R. Testa

Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation

Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh

Diagnostic and prognostic biomarkers for malignant mesothelioma: an update

Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang

Immunotherapy for malignant pleural mesothelioma: current status and future directions

Jordan Dozier, Hua Zheng, Prasad S. Adusumilli

Biology and clinical significance of circulating tumor cell subpopulations in lung cancer

Linda O’Flaherty, Harriet Wikman, Klaus Pantel

Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?

Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace

Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer

Sumitra Mohan, Francesca Chemi, Ged Brady

Biophysical technologies for understanding circulating tumor cell biology and metastasis

Derrick W. Su, Jorge Nieva

Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer

Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno

Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer

Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Editorial

An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Yi-Lin Yang, David Jablons, Liang You

Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?

Fernando C. Santini, Siddharth Kunte, Alexander Drilon

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis

Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

China Lung Cancer Research Highlight

Dll4/Notch1 signaling from tip/stalk endothelial cell specification to stroma-dependent lung tumor inhibition: a flavor of Dll4/Notch1 pleiotropy in tumor cell biology

Maria Felice Brizzi, Paola Defilippi

Editorials

Dulanermin in cancer therapy: Still much to do

Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data

Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner

Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung

Pedro Mendez, Jose Luis Ramirez

Role of HGF/MET axis in resistance of lung cancer to contemporary management

Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr

Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review

Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Ceritinib

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

Daniel B. Costa

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack

Lorenza Landi, Federico Cappuzzo

Nivolumab

Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced non-small cell lung cancer

Arun Rajan, James L. Gulley

Brief Report

The role of Imaging and Radiation Oncology Core for precision medicine era of clinical trial

Ying Xiao, Mark Rosen

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung

Yoon Jin Cha, Hyo Sup Shim

Immunohistochemistry for predictive biomarkers in non-small cell lung cancer

Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article

Feasibility of multimodality treatment, including pleurectomy decortication, in carefully selected patients with sarcomatoid mesothelioma

Moshe Lapidot, Emanuele Mazzola, Raphael Bueno

Published online: 26 January 2026

Original Article

Construction and validation of a CT-based radiomics-deep learning signature for non-invasive prediction of PD-L1 expression and immunotherapy outcomes in non-small cell lung cancer

Yudie Pan, Tao Yang, Ting Xu, Yan Luo, Changsi Jiang, Xiaowen Liu, Jingshan Gong

Published online: 26 January 2026

Review Article

Utility of various programmed death-ligand 1 (PD-L1) assays in predicting the clinical benefit of immune checkpoint inhibitors in PD-L1-expressing non-small-cell lung cancer patients: a systematic review

Ross A. Soo, Darren Wan-Teck Lim, James Chih-Hsin Yang, Jin-Yuan Shih, Roy S. Herbst

Published online: 26 January 2026

Original Article

Clinicopathological characteristics associated with intrapulmonary metastasis rather than single primary lung cancer at first diagnosis: a study based on the Surveillance, Epidemiology, and End Results database using Bayesian networks and structural equation modeling

Wei Liu, Junko C. S. Chan, Aliss T. C. Chang, Joyce W. Y. Chan, Rainbow W. H. Lau, Tony S. K. Mok, Calvin S. H. Ng

Published online: 26 January 2026

Original Article

Retrospective study on the tolerability using a four-cycle completion in elderly patients with extensive-stage small-cell lung cancer: a body mass index-based analysis

Yuto Terashima, Susumu Takeuchi, Yusuke Ishibashi, Erika Miyake, Keiki Miyadera, Takehiro Tozuka, Yasuhiro Kato, Aya Fukuizumi, Kakeru Hisakane, Shinji Nakamichi, Akihiko Miyanaga, Kazuo Kasahara, Masahiro Seike

Published online: 26 January 2026

Original Article

A CT imaging-based deep learning model for predicting EGFR and KRAS mutations in non-small cell lung cancer: toward personalized treatment approaches

Junxian Li, Yuchen Xing, Ximin Gao, Zhaoxiang Ye, Meng Wang, Fengju Song

Published online: 26 January 2026

Original Article

Artificial intelligence-based density proportion analysis in predicting the invasiveness of neoplastic ground-glass nodules

Ting-Wei Xiong, Xiao-Chuan Zhang, Bin-Jie Fu, Wang-Jia Li, Fa-Jin Lv, Zhi-Gang Chu

Published online: 20 January 2026

Original Article

Prognostic factors of epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer treated with EGFR-tyrosine kinase inhibitor (TKI): a nationwide registry study in China

Wenhua Liang, Peiling Chen, Jianfu Li, Wenhai Fu, Xin Zheng, Jingwen Diao, Ning Wang, Xuefei Feng, Ran Zhong, Ziwen Yu, Chunyan Li, Haixuan Wang, Bo Cheng, Caichen Li, Shan Xiong, Feng Li, Yu Jiang, Yuechun Lin, Runchen Wang, Tiantian Zhang, Baohua Wang, Jing Wu, Nanshan Zhong, Jianxing He; on behalf of the China Association of Thoracic Oncology (CATO) collaboration group

Published online: 20 January 2026

Editorial Commentary

Lung cancer survivorship: natural language processing for automated abstraction of follow-up computed tomography indication

Brane Grambozov, Elvis Ruznic, Franz Zehentmayr

Published online: 16 January 2026

Letter to the Editor

Clarifying design, safety, and immune correlates in short-course hypofractionated radiotherapy for limited-stage small-cell lung cancer

Qianqian Yin, Zhongqi Wang

Published online: 16 January 2026

Review Article

Pathophysiology and treatment of leptomeningeal metastases in lung cancer

Toyoaki Hida

Published online: 16 January 2026

Case Report

Comprehensive genomic profiling of synchronous invasive adenocarcinoma and squamous cell carcinoma within the same lobe: a case report

Da Hyun Kang, Green Hong, Yoonjoo Kim, Joo-Eun Lee, Dahye Lee, Min-Kyung Yeo, Hyun-Yi Kim, Chaeuk Chung

Published online: 16 January 2026

Case Report

A comprehensive clinical trajectory of EGFR A763_Y764insFQEA-positive non-small cell lung cancer treated with fifth-line osimertinib following circulating tumor DNA-based detection: a case report

Tomohiro Oba, Kenji Kusano, Hidekazu Matsushima

Published online: 17 December 2025

Journal Highlight more

Translational Lung Cancer Research is an international, peer-reviewed, open-access journal indexed by Science Citation Index Expanded (SCIE) and PubMed/PubMed Central, focusing on cutting-edge development on the transition from preclinical to clinical research, including but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention, and technical advances related to lung cancer and relevant thoracic diseases.