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Original Article

Development of a predictive model for lymph node metastasis in esophageal cancer using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) semi-quantitative parameters and tumor biomarkers
Nan Li, Min Huang, Wenjun Bao, Chenmin Ding, Xibao Mao
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2515-2526
.
Survival analysis of small cell carcinoma of the esophagus: a 15-year retrospective study from a high-incidence region
Wei Zhang, Jie Yuan, Baihua Yang, Jiezhong Wang, Mingqiu Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2527-2538
.
First-line PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone for advanced esophageal and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of randomized controlled trials
Sijia Ren, Xikai Zhang, Xiao Zhou, Xianyuan Miao, Qiongqiong Wang, Yefang Lao, Zhongzhong Peng, Kaifeng Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2539-2552
.
The clinical efficacy and pathological assessment of neoadjuvant imatinib treatment in patients with primary gastrointestinal stromal tumors
Chunhui Shou, Weili Yang, Xue Zhang, Xiaodong Wang, Qing Zhang, Jiren Yu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2553-2564
.
mTLS status predicts survival benefit from adjuvant chemotherapy in gastric cancer patients treated with neoadjuvant therapy and surgery
Dan Liu, Chenyu Tian, Bosen Li, Xinyou Liu, Chengbo Ji, Yihong Sun, Junjie Zhao, Haojie Li, Xuefei Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2565-2583
.
Trifluridine/tipiracil (FTD/TPI) in advanced gastric cancer—a retrospective cohort study providing real-world survival and safety data from the United Kingdom
Joseph Salf, Aimee Cunningham, Dinakshi Shah, Victoria Kunene, Sudha Karanam, Ellanna Griffin, Hannah-Leigh Gray, Harry Potts, Hebaalah Elsandoby, Hossam Abdulkhalek, James Bennett, Samuel L. Hill, Fangfei Gao, Robert Kitson, Donald McLeod, Edward Park, Martin Scott-Brown, Elizabeth Smyth, Was Mansoor, Russell D. Petty, Mark A. Baxter
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2584-2591
.
Parenteral nutrition versus enteral nutrition after gastric cancer surgery: a systematic review and meta-analysis of randomized controlled trials
Liping Yang, Lihua Yang, Ling Yang, Chao Xia, Chaonan Fei, Peibei Duan
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2592-2602
.
Trends of mortality among patients with malignant neoplasms of digestive system in the United States from 2007 to 2021
Yu Hua, Yuting Zhang, Shangcheng Yan, Yichun Zhu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2603-2612
.
The effect of neoadjuvant chemoradiotherapy on perioperative outcomes in rectal cancer patients following stoma reversal—a retrospective cohort analysis
Mary Junak, Rosemarie Turk, Mohammad Afaque Alam, Eli Thompson, David Schaub, Joseph Gunderson, Anesu S. Masango, Srikar Kollipara, Andrea Moreno, Daniom Tecle, Valentine N. Nfonsam
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2613-2619
.
The optimal number of lymph nodes examined for rectal cancer patients undergoing neoadjuvant long-course chemoradiotherapy
Kexing Xi, Lin Feng, Tianlei Xu, Lin Zhang, Yuelu Zhu, Hui Fang, Haizeng Zhang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2620-2631
.
Predicting bevacizumab efficacy: the emerging role of ACTL6B in colorectal cancer
Xia Weng, Jiyun Zhu, Xiaoshuai Zhou
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2632-2650
.
A prognostic nomogram for colorectal cancer: integrating blood microbiome and clinical factors
Hui Yang, Xiaoli Liu, Dajin Yuan, Huimin Li, Xiaofeng Mu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2651-2663
.
Bibliometric analysis on the correlation between colorectal cancer and tumor microenvironment [2009–2024]
Longjun Huang, Wenjuan He, Jian Zheng, Yong Guo, Jianzhong Gu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2664-2685
.
Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: a systematic review and meta-analysis
Jahnavi Udaikumar, Sushrut Ingawale, Rithish Nimmagadda, Satwik Kuppili, Vindhya Vasini Lella, Tarun Kumar Suvvari, Abraham Cheloff, Amulya Bellamkonda, Suprabhat Giri, Paul Oberstein, Aasma Shaukat
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2686-2702
.
ZNF454-FSTL3 axis inhibits colorectal cancer progression by inhibiting HIF-1α-mediated glycolysis in hypoxia
Pingfei Tang, Yueming Wu, Lin Tan, Chao Zhang, Liping Qin, Dajun Wu
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2703-2718
.
Glutaryl-CoA dehydrogenase: a key biomarker linking lysine degradation to hepatocellular carcinoma metastasis and prognosis via NF-KB signaling pathway
Qiuhui Hu, Shizhuan Huang, Zhizhou Li, Yang Yu, Shan Yu, Dehai Wu, Sheng Tai
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2719-2730
.
Safety and efficacy of transcatheter chemoembolization combined with hepatic arterial infusion chemotherapy for unresectable primary liver cancer: a single-center prospective study
Chi Xu, Jiapeng Sun, Qiongyu Liang, Yanli Lu, Jie Pan
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2731-2740
.
Efficacy and safety of tyrosine kinase inhibitors combined with sintilimab and transarterial chemoembolization in patients with Barcelona Clinic Liver Cancer stage B/C hepatocellular carcinoma: a pooled analysis
Gen-Lin Lu, Jin-Ming Tu, Asadullah Hussainzai, Fei Tong, Renya Jiang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2741-2749
.
Predicting the prognosis of hepatocellular carcinoma after curative resection using a nomogram based on the ratio of prealbumin to platelet distribution width
Junbei Zhu, Jianhao Huang, Qiang Wang, Kai He
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2750-2774
.
Revisiting the role of postoperative adjuvant transarterial chemoembolization in hepatocellular carcinoma: a propensity score matching analysis
Jia-Jun Li, Ye Xu, Hua-Hua Liu, Mao-Pei Chen, Yi Chen, Ning-Ling Ge, Lan Zhang, Zheng-Gang Ren, Xin-Rong Yang, Rong-Xin Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2775-2788
.
Survival outcomes of patients after liver transplantation for patients with hepatocellular carcinoma exceeding the Hangzhou criteria
Zhi-Ping Huang, Shu-Tong Lu, Jin Du, Ren-Dong Liu, Qing Ouyang, Bao Zhang, Meng-Chao Wang, Diamantis I. Tsilimigras, Hani M. Wadei, Yu-Jian Zheng, Shao-Ping Wang, Feng Huo, Xiao-Yu Tan, Jian-Xiong Chen
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2789-2801
.
Landscape targeted of therapy in advanced pancreatic adenocarcinoma: a network meta-analysis of randomized controlled trials [2010–2024]
Huixin Ma, Sheng Wang, Yunjin Ya, Yun Jin, Shikang Deng
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2802-2813
.
Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus
Rei Takahashi, Akira Saito, Hideyo Miyato, Yuki Kimura, Yuichi Aoki, Masanobu Taguchi, Kazue Morishima, Hideyuki Ohzawa, Kazuhiro Endo, Hideki Sasanuma, Hironori Yamaguchi, Hiroshi Kawahira, Hisanaga Horie, Yoshinori Hosoya, Toshiki Mimura, Joji Kitayama, Naohiro Sata
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2814-2826
.
The value of lipid metabolism-related genes in pancreatic cancer immunotherapy and drug prediction
Runxin Xue, Zhiwei Tao, Rui Bai, Yan Shao, Na Liu, Chuying Wang
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2827-2846
.
Lumbar centroid level subcutaneous fat volume increased performance of prognostic predictive model in digestive system cancers: a real-world cohort study
Lin Zheng, Jun-Li Zhang, Li-Li Wu, Rong-Jun Shao, Xiao-Xuan Ye, Wei-Cheng Li, Liang Zhang, Yu-Yue Zhang, Feng-Ming Zhang, Yu-Hang Ye, Xiao-Wei Le, Teng Zhang, En-Yu Wang, Rui-Zhi Ye, Guang-Xian You, Rong-Biao Ying, Ru-Xuan Yan, Zhi-Rui Zhou
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2847-2863
.

Case Report

Hypercalcemia in metastatic pancreatic neuroendocrine tumor: a case report of ectopic 1,25 hydroxyvitamin D production by tumor cells and tumor-associated macrophages
Sue Mei Lau, Ayanthi Wijewardene, Koroush Haghighi, Anthony J. Gill, Frederic Sierro
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2864-2872
.
Staged approach to overcome hyperbilirubinemia: tailored chemotherapy in liver metastases-a case report
Shadi Chamseddine, Khalil Choucair, Muhammad Wasif Saif
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2873-2880
.
Multidisciplinary team approach of treatment of a metastatic gastric carcinoma during pregnancy: a case report
Job F. H. Eijsink, Joost N. Udo, Jan Gerard Maring, Rieneke T. Lugtenberg, Helle-Brit Fiebrich
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2881-2886
.
Intraocular metastasis from an anal squamous cell carcinoma: a case report
Sameeha Sajid, Muhammad Daud Abdullah, Ammar Yousif
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2887-2890
.

Editorial

Claudin 18.2 in gastroesophageal adenocarcinoma: prevalence, biomarker associations, and implications for equity
Yassine Alami Idrissi, Alina Zatsepina, Anwaar Saeed
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2891-2894
.

Editorial Commentary

Right place right time: the role of immunotherapy in patients with locally advanced gastric/gastroesophageal junction adenocarcinoma
Abigail Fong, Dani Castillo, Pranati Shah, Sophia Guzman, Gagandeep Brar
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2895-2899
.
Potential of regorafenib in late-line treatment for refractory advanced gastric cancer
Chikara Kunisaki
Journal of Gastrointestinal Oncology  
2025;
16
(6)
:2900-2904
.
Review Article 
Colorectal carcinoma: Pathologic aspects
Matthew Fleming, Sreelakshmi Ravula, Sergei F. Tatishchev, Hanlin L. Wang
Published online: 01 September 2012
Review Article 
HDR brachytherapy for anal cancer
Peter Niehoff, Gyoergy Kovács
Published online: 30 June 2014
Review Article 
Gastric cancer: Classification, histology and application of molecular pathology
Bing Hu, Nassim El Hajj, Scott Sittler, Nancy Lammert, Robert Barnes, Aurelia Meloni-Ehrig
Published online: 01 September 2012
Review Article 
Immunohistochemical features of the gastrointestinal tract tumors
Hannah H. Wong, Peiguo Chu
Published online: 01 September 2012
Review Article 
Postoperative management after hepatic resection
Lindsay J. Wrighton, Karen R. O’Bosky, Jukes P. Namm, Maheswari Senthil
Published online: 01 March 2012
Original Articles 
Change in CA 19-9 levels after chemoradiotherapy predicts survival in patients with locally advanced unresectable pancreatic cancer
Gary Y. Yang, Nadia K. Malik, Rameela Chandrasekhar, Wen-Wee Ma, Leayn Flaherty, Renuka Iyer, Boris Kuvshinoff, John Gibbs, Gregory Wilding, Graham Warren, Kilian Salerno May
Published online: 26 December 2013
Review Article 
Techniques of hepatic resection
Robert J. Aragon, Naveenraj L. Solomon
Published online: 01 March 2012
Case Report 
Effectiveness of radiation therapy in GIST: A case report
Joshua Halpern, Yong-June Kim, Rumana Sultana, Gina Villani
Published online: 07 June 2012
Original Article 
Association of Technetium99m MAG-3 renal scintigraphy with change in creatinine clearance following chemoradiation to the abdomen in patients with gastrointestinal malignancies
Kilian Salerno May, Gary Y Yang, Nikhil I Khushalani, Rameela Chandrasekhar, Gregory E Wilding, Leayn Flaherty, Harish K Malhotra, Richard C Russo, John C Warner, Johnny C Yap, Renuka V Iyer, Chukwumere E Nwogu, Saikrishna S Yendamuri, John F Gibbs, Hector R Nava, Dominick Lamonica, Charles R Thomas
Published online: 13 September 2010
Original Article 
Outcome of head compared to body and tail pancreatic cancer: a systematic review and meta-analysis of 93 studies
Gianluca Tomasello, Michele Ghidini, Antonio Costanzo, Antonio Ghidini, Alessandro Russo, Sandro Barni, Rodolfo Passalacqua, Fausto Petrelli
Published online: 08 April 2019
Review Article 
Diet and supplements and their impact on colorectal cancer
Marinos Pericleous, Dalvinder Mandair, Martyn E. Caplin
Published online: 26 December 2013
Case Report 
A curious discourse of Krukenberg tumor: a case report
Somak Das, Diwakar Sahu, Majid Wani, Prasanna Kumar Reddy
Published online: 20 December 2014
Case Report 
Pulmonary metastases in pancreatic cancer, is there a survival influence?
Ayham Deeb, Sulsal-Ul Haque, Olugbenga Olowokure
Published online: 01 June 2015
Original Articles 
Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma
Guy A. Weiss, Michael Rossi, Nikhil Khushalani, Ken Lo, John F. Gibbs, Anubha Bharthuar, John K. Cowell, Renuka Iyer
Published online: 22 March 2013
Review Article 
Clinical presentation, diagnosis, classification and management of peritoneal mesothelioma: a review
Alfonso García-Fadrique, Akash Mehta, Faheez Mohamed, Sanjeev Dayal, Tom Cecil, Brendan J. Moran
Published online: 19 October 2017
Review Article 
Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy
Dae Won Kim, Chetasi Talati, Richard Kim
Published online: 18 April 2017
Review Article 
Imaging preoperatively for pancreatic adenocarcinoma
Jason Alan Pietryga, Desiree E. Morgan
Published online: 01 August 2015

Original Article

Bax expression is a candidate prognostic and predictive marker of colorectal cancer
Venkat R Katkoori, Catalina Suarez-Cuervo, Chandrakumar Shanmugam, Nirag C Jhala, Tom Callens, Ludwine Messiaen, James Posey III, Harvey L Bumpers, Sreelatha Meleth, William E Grizzle, Upender Manne
Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity
Dongyun Yang, Andrew Hendifar, Cosima Lenz, Kayo Togawa, Felicitas Lenz, Georg Lurje, Alexandra Pohl, Thomas Winder, Yan Ning, Susan Groshen, Heinz-Josef Lenz
The influence of radiation therapy dose escalation on overall survival in unresectable pancreatic adenocarcinoma
William A. Hall, Lauren E. Colbert, Dana Nickleach, Jeffrey Switchenko, Yuan Liu, Theresa Gillespie, Joseph Lipscomb, Claire Hardy, David A. Kooby, Roshan S. Prabhu, John Kauh, Jerome C. Landry
Overall survival analysis of neoadjuvant chemoradiotherapy and esophagectomy for esophageal cancer
Faisal A. Siddiqui, Katelyn M. Atkins, Brian S. Diggs, Charles R. Thomas Jr, John G. Hunter, James P. Dolan
Radiotherapy patterns of care in gastric adenocarcinoma: a single institution experience
Jessica Cheng, Malcolm H. Squires III, John L. Mikell, Sarah B. Fisher, Charles A. Staley III, David A. Kooby, Bassel F. El-Rayes, Walter J. Curran Jr, William A. Hall, Lauren E. Colbert, Joseph W. Shelton, Shishir K. Maithel, Jerome Landry, David S. Yu
Impact of intensity modulated radiation therapy on survival in anal cancer
Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Sibo Tian, Richard J. Cassidy, Theresa Gillespie, Pretesh R. Patel, Jerome C. Landry, Kirtesh R. Patel
Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy
Chongkai Wang, Jun Gong, Travis Y. Tu, Peter P. Lee, Marwan Fakih
Palliative care and end-of-life health care utilization in elderly patients with pancreatic cancer
Nizar Bhulani, Arjun Gupta, Ang Gao, Jenny Li, Chad Guenther, Chul Ahn, Elizabeth Paulk, Stephanie Houck, Muhammad S. Beg
Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum
Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Pérez-Irizarry, Charles H. Cha, Caroline H. Johnson, Daniel J. Boffa, Dale Han, Kimberly L. Johung, Yawei Zhang, Sajid A. Khan

Review Article

Alcoholic liver disease- Hepatocellular carcinoma transformation
Samuel W French, James Lee, Jim Zhong, Timothy R Morgan, Virgil Buslon, William Lungo, Barbara A French
Pancreatic adenocarcinoma pathology: changing “landscape”
Lodewijk A. A. Brosens, Wenzel M. Hackeng, G. Johan Offerhaus, Ralph H. Hruban, Laura D. Wood
Refining the management of resectable esophagogastric cancer: FLOT4, CRITICS, OE05, MAGIC-B and the promise of molecular classification
Jeremy Chuang, Jun Gong, Samuel J. Klempner, Yanghee Woo, Joseph Chao

Original Articles

Socioeconomic status, p53 abnormalities, and colorectal cancer
Emily Vogtmann, Chandrakumar Shanmugam, Venkat R. Katkoori, John Waterbor, Upender Manne
Nab-paclitaxel monotherapy in refractory pancreatic adenocarcinoma
Parvin F. Peddi, May Cho, Jian Wang, Feng Gao, Andrea Wang-Gillam

Below are the latest Journal of Gastrointestinal Oncology articles published online ahead of print publication.