Dissection of key factors correlating with H5N1 avian influenza virus driven inflammatory lung injury of chicken identified by single-cell analysis
Fig 2
Global infection signature of cell types in the lung after H9N2 or H5N1 AIV infection.
Histogram showing the number of up-regulated (red) and down-regulated DEGs (green) in H5N1-infected cells (A) or H9N2-infected cells (D) compared to control cells within each cell type. Heatmap showing the normalized expression (Z-score) of the top DEGs in H5N1-infected cells (B) or H9N2-infected cells (E) compared to control cells within each cell type. Histogram showing the significantly up-regulated DEGs (log2 fold change≥0.36, and p value_ adj≤0.05) in each cell type enriched in the gene ontology term of “defense response to virus” (GO: 0051607). The ranking of genes from top to bottom is based on the mean expression level in H5N1-infected cells (C) or H9N2-infected cells (F) compared to control cells within each cell type.