Chapter 2
Organelle
• Plasma membrane
-Immunological identity
Specific receptors for hormones & chemicals.
- Some are enzymes.
-Transmembrane transport.
Organelle
• Nuclues
-All cells have nucleus except matured erythrocytes
-Largest organelle.
-Contained within a membrane with tiny pores.
-Contains the body’s genetic material (DNA).
-Control Center of the cell
-Contain CHROMATIN (loose DNA)
Organelle
• Mitochondria
-Sausageshaped in the cytoplasm.
-“Power house” of the cell.
-Synthesis of adenosine triphosphate (ATP)
Organelle
• Ribosome
-Tiny granules composed of RNA and protein.
-Free units within the cytoplasm.
-Synthesis of protein from amino acids for use within the cell.
Organelle
• Endoplasmic reticulum (ER)
Smooth ER:
-synthesis of lipids, steroid hormones, detoxification of drugs
Rough ER:
-has ribosome. Synthesis of proteins for “export”.
Organelle
• Golgi apparatus
-Stacks of closely folded flattened membranous sacs.
-Proteins synthesized from ER are moved and “packaged” here
(secretory granules) before being transferred out of the cell
Organelle
• Lysosomes
-A type of secretory vesicle formed by the Golgi apparatus.
-Breakdown of large molecules to be recycled or as waste material.
Organelle
• Microfilaments & Microtubules
-Microfilaments = tiny strands of protein for structural support.
-Microtubules= movement of organells, organization of proteins within
the plasma membrane.
Mitosis
• Prophase-chromatin condensed to form chromosomes
• ProMetaphase-Nuclear envelope breaks down
• Metaphase- The chromosomes align at the equatorial plane.
• Anaphase-Sister chromatids separate and the resultant daughter
chromosomes move toward the poles
• Telophase-Daughter chromosomes reach the poles and form two new
nuclei.
Transport of substance across cell membranes
• Passive transport
-Diffusion-Molecules and ions passing through the membrane without
using energy.
-facilitated diffusion -Diffusion with help of protein carrier, Usually for
larger molecules like glucose and amino acids.
-osmosis. Passive movement of water down its concentration gradient
across a semi permeable membrane until an equilibrium is reached
Transport of substance across cell membranes
• Active transport
-Transport of substance up their concentration gradient.
-ATP drives molecules across the plasma membrane.
-Example: Sodium Potassium Pump. Bulk Transport (Phagocytosis).
-Active transport requires energy to move substances from area of
lower concentration to area of higher concentration.
-Endocytosis move material inside the cell
-Exocytosis move material out from the cell
• Wilson’s disease protein (ATP7B) is a key regulator of copper
concentration in the liver